The Effect of Non-Invasive Brain Stimulation (NIBS) on Executive Functioning, Attention and Memory in Rehabilitation Patients with Traumatic Brain Injury: A Systematic Review.
The Effect of Non-Invasive Brain Stimulation (NIBS) on Executive Functioning, Attention and Memory in Rehabilitation Patients with Traumatic Brain Injury: A Systematic Review.
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DOI：
10.3390/diagnostics11040627
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发表时间：
2021-03-31
期刊：
影响因子：
--
通讯作者：
Burhan AM
中科院分区：
文献类型：
--
作者：
Hara T;Shanmugalingam A;McIntyre A;Burhan AM
近年来，非侵入性脑刺激（NIBS）对创伤性脑损伤（TBI）患者认知功能的潜在治疗作用已被探索。然而，目前还没有针对刺激部位和刺激参数对TBI认知障碍进行系统的NIBS综述。本研究的目的是对NIBS治疗脑外伤后认知功能障碍的有效性和安全性进行系统评价。本研究在PROSPERO系统评价数据库（CRD42020183298）进行前瞻性注册。从以下数据库检索到2020年12月31日的所有英文文章：Pubmed/MEDLINE， Scopus， CINAHL, Embase， PsycINFO和CENTRAL。随机和前瞻性对照试验，包括交叉研究，纳入分析。纳入了至少5名TBI患者的研究，其中至少提供了5次NIBS，并使用了标准化的认知神经心理学测量。共有5项研究符合入选标准。2项研究使用重复经颅磁刺激（rTMS）， 3项研究使用经颅直流刺激（tDCS）。rTMS共44人，tDCS共91人。五分之三的研究将认知训练或附加治疗（计算机辅助）与NIBS相结合。rTMS的目标症状包括注意力（n = 2）、记忆（n = 1）和执行功能（n = 2）；只有一项研究显示，与对照组相比，他们在注意力方面有了显著改善。在tDCS研究中，目标症状包括认知（n = 2）、注意（n = 3）、记忆（n = 3）、工作记忆（WM） （n = 3）和执行功能（n = 1）；三项研究中有两项显示，与对照组相比，他们在注意力和记忆力方面有了显著改善。NIBS对脑外伤患者认知功能康复的有效性证据尚处于起步阶段，需要更多的研究。在所有的研究中，都选择背外侧前额叶皮层（DLPFC）作为刺激部位，同时选择促进左侧DLPFC激活的刺激模式。在一些研究中，与对照组相比，有显著的改善，但rTMS和tDCS都没有足够的证据证明其有效性。为了建立证据，我们需要使用神经成像来评估刺激部位和相关区域的大脑活动，以了解NIBS如何作用于神经网络。
In recent years, the potential of non-invasive brain stimulation (NIBS) for therapeutic effects on cognitive functions has been explored for populations with traumatic brain injury (TBI). However, there is no systematic NIBS review of TBI cognitive impairment with a focus on stimulation sites and stimulation parameters. The purpose of this study was to conduct a systematic review examining the effectiveness and safety of NIBS for cognitive impairment after a TBI. This study was prospectively registered with the PROSPERO database of systematic reviews (CRD42020183298). All English articles from the following databases were searched from inception up to 31 December 2020: Pubmed/MEDLINE, Scopus, CINAHL, Embase, PsycINFO and CENTRAL. Randomized and prospective controlled trials, including cross-over studies, were included for analysis. Studies with at least five individuals with TBI, whereby at least five sessions of NIBS were provided and used standardized neuropsychological measurement of cognition, were included. A total of five studies met eligibility criteria. Two studies used repetitive transcranial magnetic stimulation (rTMS) and three studies used transcranial direct current stimulation (tDCS). The pooled sample size was 44 individuals for rTMS and 91 for tDCS. Three of five studies combined cognitive training or additional therapy (computer assisted) with NIBS. Regarding rTMS, target symptoms included attention (n = 2), memory (n = 1), and executive function (n = 2); only one study showing significant improvement compared than control group with respect to attention. In tDCS studies, target symptoms included cognition (n = 2), attention (n = 3), memory (n = 3), working memory (WM) (n = 3), and executive function (n = 1); two of three studies showed significant improvement compared to the control group with respect to attention and memory. The evidence for NIBS effectiveness in rehabilitation of cognitive function in TBI is still in its infancy, more studies are needed. In all studies, dorsolateral prefrontal cortex (DLPFC) was selected as the stimulation site, along with the stimulation pattern promoting the activation of the left DLPFC. In some studies, there was a significant improvement compared to the control group, but neither rTMS nor tDCS had sufficient evidence of effectiveness. To the establishment of evidence we need the evaluation of brain activity at the stimulation site and related areas using neuroimaging on how NIBS acts on the neural network.
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影响因子：
2.9
作者：
Liew SL;Santarnecchi E;Buch ER;Cohen LG
通讯作者：
Cohen LG
影响因子：
2.4
作者：
Lesniak, Marcin;Polanowska, Katarzyna;Czlonkowska, Anna
通讯作者：
Czlonkowska, Anna
影响因子：
3.1
作者：
Lee, Si A.;Kim, Myoung-Kwon
通讯作者：
Kim, Myoung-Kwon
DOI：
10.1073/pnas.1405003111
发表时间：
2014-10-14
影响因子：
11.1
作者：
Fox, Michael D.;Buckner, Randy L.;Pascual-Leone, Alvaro
通讯作者：
Pascual-Leone, Alvaro
影响因子：
3.2
作者：
Li S;Zaninotto AL;Neville IS;Paiva WS;Nunn D;Fregni F
通讯作者：
Fregni F