Exploration of bacterial community classes in major human habitats.
Exploration of bacterial community classes in major human habitats.
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DOI：
10.1186/gb-2014-15-5-r66
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发表时间：
2014-05-07
期刊：
影响因子：
12.3
通讯作者：
Weinstock GM
中科院分区：
文献类型：
--
作者：
Zhou Y;Mihindukulasuriya KA;Gao H;La Rosa PS;Wylie KM;Martin JC;Kota K;Shannon WD;Mitreva M;Sodergren E;Weinstock GM
确定细菌丰度变异是了解个体间细菌相似性的第一步。将细菌群落分类为组或群落类是根据丰度模式描述微生物分布的后续步骤。在这里，我们对人类微生物组计划236名健康受试者的粪便、鼻腔、皮肤、阴道和口腔栖息地的细菌群落进行了分析。在属水平上，我们在前鼻孔、四个皮肤部位和阴道确定了不同的群落群型。我们还确认了之前在粪便中发现的三种肠型。我们在大多数口腔部位发现了两个轮廓值较低的集群，其中细菌群落更加均匀。在一个栖息地共享一个社区班级的受试者不一定在另一个栖息地共享社区班级，除了在三个阴道部位和左右耳后皱纹的对称栖息地。人口因素，包括性别、年龄和种族，对几个栖息地的群落组成有显著影响。阴道、耳后皱纹和大便的社区课程在大约200天内是稳定的。群落组成、人口因素与群落类别的关联以及群落稳定性的展示加深了我们对人类微生物群的变异性和动态的理解。这对寻求微生物与临床表型相关性的实验设计也有重要意义。
Determining bacterial abundance variation is the first step in understanding bacterial similarity between individuals. Categorization of bacterial communities into groups or community classes is the subsequent step in describing microbial distribution based on abundance patterns. Here, we present an analysis of the groupings of bacterial communities in stool, nasal, skin, vaginal and oral habitats in a healthy cohort of 236 subjects from the Human Microbiome Project. We identify distinct community group patterns in the anterior nares, four skin sites, and vagina at the genus level. We also confirm three enterotypes previously identified in stools. We identify two clusters with low silhouette values in most oral sites, in which bacterial communities are more homogeneous. Subjects sharing a community class in one habitat do not necessarily share a community class in another, except in the three vaginal sites and the symmetric habitats of the left and right retroauricular creases. Demographic factors, including gender, age, and ethnicity, significantly influence community composition in several habitats. Community classes in the vagina, retroauricular crease and stool are stable over approximately 200 days. The community composition, association of demographic factors with community classes, and demonstration of community stability deepen our understanding of the variability and dynamics of human microbiomes. This also has significant implications for experimental designs that seek microbial correlations with clinical phenotypes.
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影响因子：
64.8
作者：
Arumugam, Manimozhiyan;Raes, Jeroen;Pelletier, Eric;Le Paslier, Denis;Yamada, Takuji;Mende, Daniel R.;Fernandes, Gabriel R.;Tap, Julien;Bruls, Thomas;Batto, Jean-Michel;Bertalan, Marcelo;Borruel, Natalia;Casellas, Francesc;Fernandez, Leyden;Gautier, Laurent;Hansen, Torben;Hattori, Masahira;Hayashi, Tetsuya;Kleerebezem, Michiel;Kurokawa, Ken;Leclerc, Marion;Levenez, Florence;Manichanh, Chaysavanh;Nielsen, H. Bjorn;Nielsen, Trine;Pons, Nicolas;Poulain, Julie;Qin, Junjie;Sicheritz-Ponten, Thomas;Tims, Sebastian;Torrents, David;Ugarte, Edgardo;Zoetendal, Erwin G.;Wang, Jun;Guarner, Francisco;Pedersen, Oluf;de Vos, Willem M.;Brunak, Soren;Dore, Joel;Weissenbach, Jean;Ehrlich, S. Dusko;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
17.1
作者：
Gajer P;Brotman RM;Bai G;Sakamoto J;Schütte UM;Zhong X;Koenig SS;Fu L;Ma ZS;Zhou X;Abdo Z;Forney LJ;Ravel J
通讯作者：
Ravel J
DOI：
10.1073/pnas.0807920105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Fierer, Noah;Hamady, Micah;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
14.9
作者：
Cole JR;Wang Q;Cardenas E;Fish J;Chai B;Farris RJ;Kulam-Syed-Mohideen AS;McGarrell DM;Marsh T;Garrity GM;Tiedje JM
通讯作者：
Tiedje JM
影响因子：
12.3
作者：
Hildebrand F;Nguyen TL;Brinkman B;Yunta RG;Cauwe B;Vandenabeele P;Liston A;Raes J
通讯作者：
Raes J