Identification and Quantification of Intrinsic Optical Contrast for Near‐infrared Mammography

Identification and Quantification of Intrinsic Optical Contrast for Near‐infrared Mammography
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近红外乳腺 X 线摄影固有光学对比度的识别和量化

DOI:
10.1111/j.1751-1097.1998.tb05159.x
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发表时间:
1998
影响因子:
3.3
通讯作者:
M. Ferrari
M. Ferrari
中科院分区:
生物学3区
文献类型:
--
作者:
V. Quaresima;S. Matcher;M. Ferrari

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近红外光谱已用于量化健康女性乳腺组织的体内成分。通过收集 5 名女性志愿者乳房 7-9 个位置的波长范围 680-1100 nm 的透照光谱,试图量化乳房成分的体内和受试者间变异性。主要吸收剂是水、脂质和血红蛋白。乳房中的血红蛋白浓度远低于大脑或肌肉中的血红蛋白浓度(低于 10 μM)。在同一乳房的不同位置之间,测得的脱氧血红蛋白浓度可能存在高达 100% 的差异。水和脂质浓度可以表现出类似的变化。模型和模拟研究表明,这种变化并不是由于组织边界对测量的影响。低血红蛋白浓度意味着光学乳腺成像应在低于约 850 nm 的波长下进行,以确保图像对比度主要来自血红蛋白。受试者体内的变异性可能会对光学成像从背景对比度变化中辨别肿瘤的能力产生影响。
Near‐infrared spectroscopy has been used to quantify the composition of healthy female breast tissue in vivo. By collecting transillumination spectra in the wavelength range 680–1100 nm at 7–9 positions on the breasts of five female volunteers, an attempt was made to quantify the intra‐ and intersubject variability of breast composition. The dominant absorbers are water, lipids and hemoglobin. Hemoglobin concentration in the breast is substantially lower than that in the brain or muscle (less than 10 μM). The measured deoxyhemoglobin concentration can vary by up to 100% between different positions on the same breast. Water and lipid concentrations can show similar variability. Phantom and simulation studies demonstrate that this variability is not due to the effects of tissue boundaries on the measurements. The low hemoglobin concentration implies that optical breast imaging should be performed at wavelengths below about 850 nm to ensure that the image contrast comes predominantly from hemoglobin. Intrasubject variability could have implications for the ability of optical imaging to discern tumors from background contrast variations.
DOI: 10.1126/science.8451643
发表时间: 1993-03-05
期刊: SCIENCE
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期刊: The American journal of physiology
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发表时间: 1997-06-10
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