Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model.
Simple quantitative measurement based on DWI to objectively judge DWI-FLAIR mismatch in a canine stroke model.
复制标题
基于 DWI 的简单定量测量客观判断犬中风模型中 DWI-FLAIR 不匹配
DOI：
10.5152/dir.2015.14443
复制
发表时间：
2015-07
影响因子：
2.1
通讯作者：
Shi Haibin
中科院分区：
文献类型：
--
作者：
Liu Sheng;Xu Xiaoquan;Cheng Qiguang;Zu Qingquan;Lu Shanshan;Yu Jing;Liu Xinglong;Wang Bin;Teng Gaojun;Shi Haibin
目的
PURPOSE
Diffusion-weighted imaging (DWI) - fluid attenuated inversion recovery (FLAIR) mismatch was proven useful to time the onset of wake-up stroke; however, identifying the status of FLAIR imaging has been mostly subjective. We aimed to evaluate the value of relative DWI signal intensity (rDWI), and relative apparent diffusion coefficient (rADC) in identifying the FLAIR status in the acute period.
METHODS
Autologous clot was used to embolize left middle cerebral artery in 20 dogs. Magnetic resonance imaging was performed 3-6 hours and 24 hours after embolization. DWI-FLAIR mismatch was defined as hyperintense signal detected on DWI, but not on FLAIR. The mean values of rDWI or rADC of FLAIR- and FLAIR+ lesions were compared and the critical cutoff values of rDWI and rADC for identifying the FLAIR status were determined.
RESULTS
Stroke models were successfully established in all animals. DWI+ lesions were found in all 20 dogs from three hours, while FLAIR+ lesions were found in three, 11, 16, 19, and 20 dogs at five time points after embolization, respectively. The mean rDWI values were significantly different between FLAIR- and FLAIR+ lesions (P < 0.001), but rADC values were not (P = 0.73). Using rDWI=1.90 as the threshold value, excellent diagnostic efficacy was achieved (AUC, 0.88; sensitivity, 0.77; specificity, 0.88). However, rADC appeared not useful (AUC, 0.48; sensitivity, 0.52; specificity, 0.58) in identifying the FLAIR status.
CONCLUSION
In our embolic canine stroke model, rDWI was useful to identify FLAIR imaging status in the acute period, while rADC was not.
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影响因子：
2.9
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通讯作者：
Wardlaw, JM
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影响因子：
3.7
作者：
Lu SS;Liu S;Zu QQ;Xu XQ;Yu J;Wang JW;Zhang Y;Shi HB
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6.3
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影响因子：
3
作者：
Liu, Sheng;Hu, Wei-Xing;Shi, Hai-Bin
通讯作者：
Shi, Hai-Bin