Association between 5-min Apgar score and attention deficit hyperactivity disorder: a Scotland-wide record linkage study of 758,423 school children.
Association between 5-min Apgar score and attention deficit hyperactivity disorder: a Scotland-wide record linkage study of 758,423 school children.
复制标题
DOI：
10.1186/s12888-023-05217-6
复制
发表时间：
2023-10-31
期刊：
影响因子：
4.4
通讯作者：
Fleming, Michael
中科院分区：
文献类型：
--
作者：
Bala, Jecintha J.;Bala, Joel D.;Pell, Jill P.;Fleming, Michael
关键词：
大约二十分之一的儿童患有注意力缺陷多动障碍 (ADHD)，并会造成终生后遗症。先前关于阿普加评分与多动症之间关联的研究报告了不一致的结果。使用孕产、处方和小学生人口普查数据库的记录关联，对 2009 年至 2013 年间在苏格兰出生并在苏格兰上学的单胎儿童进行人口电子队列研究。使用二元逻辑回归分析来调查 5 分钟阿普加评分与针对社会人口统计学和孕产混杂因素进行调整后的治疗 ADHD 之间的关联。在 758,423 名儿童中，7,292 名（0.96%）接受了多动症药物治疗。结果表明，阿普加评分与治疗的 ADHD 之间存在潜在的剂量反应关系，且与混杂因素无关。就 Apgar 评分为 10 分而言，得分为 0-3（调整后 OR 1.76，95% CI 1.32-2.34）、4-6（调整后 OR 1.50，95% CI 1.21-1.86）甚至 7-9（调整后 OR 1.26，95% CI 1.18-1.36）时，治疗 ADHD 的风险较高。传统上认为属于正常范围。除了强调通过良好的产科实践最大化阿普加评分的必要性之外，研究结果表明阿普加评分可能有助于预测未来 ADHD 的风险，从而促进早期诊断和治疗。
Attention-deficit hyperactivity disorder (ADHD) affects around 1 in 20 children and is associated with life-long sequelae. Previous studies of the association between Apgar score and ADHD have reported inconsistent findings. Record linkage of maternity, prescribing and school pupil census databases was used to conduct a population e-cohort study of singleton children born in Scotland and attending school in Scotland at any point between 2009 and 2013. Binary logistic regression analysis was used to investigate the association between 5-min Apgar score and treated ADHD adjusting for sociodemographic and maternity confounders. Of the 758,423 children, 7,292 (0.96%) received ADHD medication. The results suggested a potential dose–response relationship between Apgar score and treated ADHD independent of confounders. Referent to an Apgar score of 10, risk of treated ADHD was higher for scores of 0–3 (adjusted OR 1.76, 95% CI 1.32–2.34), 4–6 (adjusted OR 1.50, 95% CI 1.21–1.86) and even 7–9 (adjusted OR 1.26, 95% CI 1.18–1.36) which are traditionally considered within the normal range. In addition to reinforcing the need to maximise Apgar score through good obstetric practice, the findings suggest that Apgar score may be useful in predicting future risk of ADHD and therefore facilitating early diagnosis and treatment.
登录
查看更多内容
影响因子：
5.3
作者：
Brake, WG;Sullivan, RM;Gratton, A
通讯作者：
Gratton, A
影响因子：
5.4
作者：
McKechnie, Douglas G. J.;O'Nions, Elizabeth;Dunsmuir, Sandra;Petersen, Irene
通讯作者：
Petersen, Irene
DOI：
10.1111/j.1469-7610.1992.tb00926.x
发表时间：
1992-09-01
期刊：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY AND ALLIED DISCIPLINES
影响因子：
--
作者：
CHANDOLA, CA;ROBLING, MR;MCGUFFIN, P
通讯作者：
MCGUFFIN, P
影响因子：
3.8
作者：
Mikkelsen, Susanne Hvolgaard;Olsen, Jorn;Arah, Onyebuchi
通讯作者：
Arah, Onyebuchi
影响因子：
--
作者：
Juárez Olguín H;Calderón Guzmán D;Hernández García E;Barragán Mejía G
通讯作者：
Barragán Mejía G