Acute pancreatitis and COVID-19: A literature review.
Acute pancreatitis and COVID-19: A literature review.
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DOI：
10.4240/wjgs.v13.i6.574
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发表时间：
2021-06-27
影响因子：
2
通讯作者：
Rocha M
中科院分区：
文献类型：
--
作者：
Correia de Sá T;Soares C;Rocha M
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）是目前正在流行的2019冠状病毒病（COVID-19）的罪魁祸首，已在全球造成8000多万例感染和170万人死亡。虽然它主要是一种呼吸道病毒，但SARS-CoV-2也有肺外效应。胰腺损伤和急性胰腺炎（AP）病例已被确认并归因于SARS-CoV-2，但胰腺损伤的机制仍是一个有争议的话题。SARS-CoV-2是否会引发AP，还是只是附带现象，也存在争议。目的回顾和探讨SARS-CoV-2感染与AP的关系，并对SARS-CoV-2致胰腺病变可能机制的现有文献进行综述。按照PRISMA指南对SARS-CoV-2感染和AP相关论文进行系统综述，并对SARS-CoV-2诱导胰腺病变的可能机制进行叙述性综述。一项文献综述显示，关于sars - cov -2诱导胰腺病变的证据越来越多，包括病毒直接介导的损伤机制、全身炎症反应和循环促炎白介素、病毒诱导的脂肪毒性和药物诱导的损伤。对文献的系统回顾显示，COVID-19患者中有22例AP。然而，报告病例的局限性使得很难建立SARS-CoV-2感染与AP之间的因果关系。由于临床进展、治疗意义和预后尚不清楚，所有研究都同意对这部分患者进行特殊监测和监测。在COVID-19患者中应考虑AP，特别是那些表现出腹痛和系统完整报告这些病例的患者应成为一般做法。然而，目前仍没有足够的证据表明COVID-19可导致AP或对预后产生负面影响。需要进一步的研究来阐明这两种实体之间的关系及其诊断意义。
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing pandemic of coronavirus disease 2019 (COVID-19), and has caused more than 80 million infections and 1.7 million deaths worldwide. Although it is primarily a respiratory virus, SARS-CoV-2 also has extra-pulmonary effects. Pancreatic injury and cases of acute pancreatitis (AP) have been recognized and attributed to SARS-CoV-2, but the mechanisms of pancreatic injury are still a subject of debate. There is also controversy on whether SARS-CoV-2 can cause AP or if it is an epiphenomenon. To review and to explore the relationship between SARS-CoV-2 infection and AP, and to provide an overview of the existing literature on possible mechanisms of SARS-CoV-2-induced pancreatic lesion. A systematic review was conducted in accordance with PRISMA guidelines for papers on SARS-CoV-2 infection and AP. A narrative review on possible mechanisms of SARS-CoV-2-induced pancreatic lesion was also performed. A literature review revealed a growing body of evidence on SARS-CoV-2-induced pancreatic lesions including the mechanisms of direct virus-mediated injury, systemic inflammatory response and circulating pro-inflammatory interleukins, virus-induced lipotoxicity, and drug-induced injury. A systematic review of the literature revealed 22 cases of AP in COVID-19 patients. However, limitations of the reported cases make it difficult to establish a causal relationship between SARS-CoV-2 infection and AP. All of the studies agreed on special monitoring and surveillance of this subset of patients due to the still unknown clinical progression, therapeutic implications, and prognosis. AP should be considered in COVID-19 patients, especially in those exhibiting abdominal pain and systematic, and complete reporting of these cases should be general practice. However, there is still insufficient evidence showing that COVID-19 can cause AP or negatively impact prognosis. Additional studies are needed to clarify the relationship between these two entities and their theragnostic significance.
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影响因子：
3
作者：
Hackert, Thilo;Hartwig, Werner;Werner, Jens
通讯作者：
Werner, Jens
影响因子：
15.1
作者：
Convertino, Irma;Tuccori, Marco;Blandizzi, Corrado
通讯作者：
Blandizzi, Corrado
影响因子：
3.6
作者：
Hadi, Amer;Werge, Mikkel;Gluud, Lise Lotte
通讯作者：
Gluud, Lise Lotte
DOI：
10.4269/ajtmh.20-0894
发表时间：
2020-10
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Ibrahim YS;Karuppasamy G;Parambil JV;Alsoub H;Al-Shokri SD
通讯作者：
Al-Shokri SD
DOI：
10.12890/2020_001710
发表时间：
2020-01-01
影响因子：
--
作者：
Meireles, Pedro Antunes;Bessa, Filipe;Alvoeiro, Lourdes
通讯作者：
Alvoeiro, Lourdes