Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects.
Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects.
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水凝胶为基础的策略椎间盘再生：进展，挑战和临床前景。
DOI：
10.3390/gels10010062
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发表时间：
2024-01-15
期刊：
影响因子：
4.6
通讯作者：
Moss, Isaac L.
中科院分区：
文献类型：
--
作者：
Desai, Shivam U.;Srinivasan, Sai Sadhananth;Kumbar, Sangamesh Gurappa;Moss, Isaac L.
全球数百万人患有与椎间盘（IVD）退变相关的腰痛和残疾。椎间盘退变与衰老高度相关，因为髓核（NP）脱水以及纤维环（AF）出现裂隙，这常常导致椎间盘突出或椎间隙塌陷以及相关临床症状。目前治疗椎间盘退变的可用方法是通过治疗手段和/或药物控制症状，以及有或无脊柱融合的椎间盘手术切除。因此，对于这种普遍存在的疾病，迫切需要更有效的疾病修饰治疗方法，而不是目前仅侧重于症状控制的模式。水凝胶是独特的生物材料，具有多种独特性质，包括（但不限于）生物相容性、高度可调节的力学特性，以及最重要的是，能够以类似于天然人类髓核组织的方式吸收和保持水分。近年来，多种水凝胶已在体外和体内进行了椎间盘修复的研究，其中一些已准备好进行临床试验。在这篇综述中，我们总结了水凝胶技术在椎间盘修复和再生应用中的最新发现和进展。
Millions of people worldwide suffer from low back pain and disability associated with intervertebral disc (IVD) degeneration. IVD degeneration is highly correlated with aging, as the nucleus pulposus (NP) dehydrates and the annulus fibrosus (AF) fissures form, which often results in intervertebral disc herniation or disc space collapse and related clinical symptoms. Currently available options for treating intervertebral disc degeneration are symptoms control with therapy modalities, and/or medication, and/or surgical resection of the IVD with or without spinal fusion. As such, there is an urgent clinical demand for more effective disease-modifying treatments for this ubiquitous disorder, rather than the current paradigms focused only on symptom control. Hydrogels are unique biomaterials that have a variety of distinctive qualities, including (but not limited to) biocompatibility, highly adjustable mechanical characteristics, and most importantly, the capacity to absorb and retain water in a manner like that of native human nucleus pulposus tissue. In recent years, various hydrogels have been investigated in vitro and in vivo for the repair of intervertebral discs, some of which are ready for clinical testing. In this review, we summarize the latest findings and developments in the application of hydrogel technology for the repair and regeneration of intervertebral discs.
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