Gender differences in lifetime alcohol dependence: results from the national epidemiologic survey on alcohol and related conditions.
Gender differences in lifetime alcohol dependence: results from the national epidemiologic survey on alcohol and related conditions.
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DOI：
10.1111/acer.12158
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发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
Blanco C
中科院分区：
文献类型：
--
作者：
Khan S;Okuda M;Hasin DS;Secades-Villa R;Keyes K;Lin KH;Grant B;Blanco C
广泛的临床文献已经注意到酒精依赖（AD）个体的病因和临床特征的性别差异。尽管有了这些知识，许多重要的问题仍然存在。利用2001年至2002年全国酒精及相关疾病流行病学调查（n = 43093），我们研究了男性（n = 2974）和女性（n = 1807）终生AD患者的社会人口学特征、精神和医学合并症、临床相关性、危险因素和治疗利用模式的差异。患有终生阿尔茨海默病的男性比女性更有可能被诊断为任何物质使用障碍和反社会人格障碍，而女性更有可能患有情绪和焦虑障碍。在对一般人群中精神共病的社会人口学特征和性别差异进行调整后，AD仅在女性中与外化障碍和任何情绪障碍有关。患有阿尔茨海默病的男性符合更多的标准，发作时间更长，而且第一次喝酒的年龄更小。缓解率没有性别差异。患有阿尔茨海默病的女性更有可能有家庭和配偶有酒精使用障碍史。男女的治疗率都很低，女性更有可能将社会污名作为治疗障碍。终生AD患者在精神合并症、危险因素、临床特征和治疗利用模式方面存在重要的性别差异。
An extensive clinical literature has noted gender differences in the etiology and clinical characteristics of individuals with alcohol dependence (AD). Despite this knowledge, many important questions remain. Using the 2001 to 2002 National Epidemiologic Survey on Alcohol and Related Conditions (n = 43,093), we examined differences in sociodemographic characteristics, psychiatric and medical comorbidities, clinical correlates, risk factors, and treatment-utilization patterns of men (N = 2,974) and women (N = 1,807) with lifetime AD. Men with lifetime AD were more likely than women to be diagnosed with any substance use disorder and antisocial personality disorder, whereas women were more likely to have mood and anxiety disorders. After adjusting for sociodemographic characteristics and gender differences in psychiatric comorbidity in the general population, AD was associated with externalizing disorders and any mood disorder among women only. Men with AD met more criteria, had longer episodes, and were younger at the age of first drink. There were no gender differences in remission rates. Women with AD were more likely to have a family and a spouse with history of alcohol use disorders. Treatment rates were low for both genders, and women were more likely to report social stigmatization as a treatment barrier. There are important gender differences in the psychiatric comorbidities, risk factors, clinical characteristics, and treatment-utilization patterns among individuals with lifetime AD.
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DOI：
10.15288/jsa.1997.58.365
发表时间：
1997-07-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Grant, BF
通讯作者：
Grant, BF
DOI：
10.15288/jsa.1998.59.97
发表时间：
1998-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
Dawson, DA;Grant, BF
通讯作者：
Grant, BF
DOI：
10.1111/j.1530-0277.2008.00719.x
发表时间：
2008-08-01
影响因子：
3.2
作者：
Grucza, Richard A.;Norberg, Karen;Bierut, Laura J.
通讯作者：
Bierut, Laura J.
影响因子：
4.2
作者：
Alvanzo, Anika A. H.;Storr, Carla L.;Crum, Rosa M.
通讯作者：
Crum, Rosa M.
影响因子：
4.2
作者：
Grant, BF;Dawson, DA;Pickering, R
通讯作者：
Pickering, R