Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice
Ultraviolet A Eye Irradiation Ameliorates Atopic Dermatitis via p53 and Clock Gene Proteins in NC/Nga Mice
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紫外线 A 眼照射通过 p53 和时钟基因蛋白改善 NC/Nga 小鼠特应性皮炎
DOI：
10.1111/php.12853
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发表时间：
2018
影响因子：
3.3
通讯作者：
Yokoyama Satoshi
中科院分区：
文献类型：
--
作者：
Hiramoto Keiichi;Yamate Yurika;Yokoyama Satoshi
特应性皮炎（AD）是一种广泛的慢性皮肤病，严重影响生活质量，并可能导致更严重的并发症。虽然紫外线（UV）A眼睛照射可以对皮肤产生各种影响，但UVA是否会影响AD尚不清楚。为了研究潜在的关联，我们使用了AD的NC/Nga小鼠模型来研究UVA眼睛照射的影响。使用FL 20 SBLB ‐A灯以100 kJ m− 2的UVA剂量照射小鼠眼睛。我们的组织学数据表明，AD症状可以改善UVA眼睛照射。我们还观察到UVA照射眼睛的小鼠中促肾上腺皮质激素（ACTH）、p53和类维生素A X受体α（RXRα）水平升高。与此相反，胸腺基质淋巴细胞生成素（TSLP），周期2（PER 2）和分化的胚胎软骨细胞1（DEC 1）蛋白的水平在UVA照射处理的小鼠下降。此外，与未照射的小鼠相比，UVA眼照射的小鼠表现出DEC 1和RXRα共定位减少。这些结果表明，p53和各种时钟基因蛋白发挥了重要作用，在改善AD症状后观察到的UVA眼睛照射，这种技术可能有治疗AD的应用。
Atopic dermatitis (AD) is a widespread chronic skin condition that severely affects quality of life and can lead to more serious complications. Although ultraviolet (UV)A eye irradiation can exert various effects on the skin, it is unknown whether UVA can affect AD. To investigate potential associations, we used an NC/Nga mouse model of AD to study the effects of UVA eye irradiation. The eyes of mice were irradiated with a UVA dose of 100 kJ m−2using a FL20SBLB‐A lamp. Our histological data demonstrated that AD symptoms could be ameliorated by UVA eye irradiation. We also observed an increase in the levels of adrenocorticotropic hormone (ACTH), p53 and retinoid X receptorα(RXRα) in mice with UVA‐irradiated eyes. In contrast, the levels of thymic stromal lymphopoietin (TSLP), period 2 (PER2) and differentiated embryo chondrocytes 1 (DEC1) protein were decreased in mice treated with UVA irradiation. Furthermore, UVA eye‐irradiated mice exhibited reduced DEC1 and RXRαcolocalization compared with nonirradiated mice. These results suggested that p53 and various clock gene proteins played important roles in the amelioration of AD symptoms observed after UVA eye irradiation; this technique may have therapeutic applications in AD.
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高剂量UVA-1放射治疗对表皮朗格汉斯细胞表面标志物和功能影响的研究
影响因子：
3
作者：
S. Gruner;T. Hofmann;H. Meffert;N. Sönnichsen
通讯作者：
N. Sönnichsen
影响因子：
2.8
作者：
Suto, H;Matsuda, H;Ra, C
通讯作者：
Ra, C
DOI：
10.1073/pnas.0507385102
发表时间：
2005-10-11
影响因子：
11.1
作者：
Li, M;Messaddeq, N;Chambon, P
通讯作者：
Chambon, P
种系 p53 突变细胞中 DNA 损伤相关的细胞周期失调和细胞凋亡控制。
影响因子：
11.2
作者：
K. Goi;Masatoshi Takagi;Satoshi Iwata;Domenico Delia;Minoru Asada;Rosangela Donghi;Yukiko Tsunematsu;Shinpei Nakazawa;Hiroshi Yamamoto;Jun Yokota;Kazuo Tamura;Y. Saeki;Joji Utsunomiya;Takashi Takahashi;R. Ueda;Chikashi Ishioka;Mariko Eguchi;Nanao Kamata;Shuki Mizutani
通讯作者：
Shuki Mizutani
影响因子：
14.2
作者：
Gelfand, Erwin W.
通讯作者：
Gelfand, Erwin W.