Modulation of steady state functional connectivity in the default mode and working memory networks by cognitive load.
Modulation of steady state functional connectivity in the default mode and working memory networks by cognitive load.
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通过认知负载调制默认模式和工作内存网络的稳态功能连接。
DOI：
10.1002/hbm.21138
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发表时间：
2011-10
影响因子：
4.8
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Newton, Allen T.;Morgan, Victoria L.;Rogers, Baxter P.;Gore, John C.
静息状态下血氧水平依赖(BOLD)磁共振成像(FMRI)信号之间的区域间相关性被解释为整个大脑连通性的衡量标准。在这里，我们研究工作记忆和默认模式网络中的这种连接是否受到认知负荷变化的调节。在三种不同条件下(N=1、2和3)以及在静息状态下，在稳态言语认同N-back任务中测量功能连接性。我们发现，随着认知负荷的增加，工作记忆和默认模式网络中的功能连接性都会增加。为了测试工作记忆和默认模式网络之间的功能连接是否发生了变化，我们构建了工作记忆网络整体的功能连接地图，发现在后扣带皮质的背侧区域出现了越来越多的负相关性。这些结果进一步证明BOLD信号的低频波动反映了神经活动的变化，并表明默认模式网络和其他认知网络之间的相互作用。
Interregional correlations between blood oxygen level dependent (BOLD) magnetic resonance imaging (fMRI) signals in the resting state have been interpreted as measures of connectivity across the brain. Here we investigate whether such connectivity in the working memory and default mode networks is modulated by changes in cognitive load. Functional connectivity was measured in a steady-state verbal identity N-back task for three different conditions (N = 1, 2, and 3) as well as in the resting state. We found that as cognitive load increases, the functional connectivity within both the working memory the default mode network increases. In order to test whether functional connectivity between the working memory and the default mode networks changed, we constructed maps of functional connectivity to the working memory network as a whole and found that increasingly negative correlations emerged in a dorsal region of the posterior cingulate cortex. These results provide further evidence that low frequency fluctuations in BOLD signals reflect variations in neural activity and suggests interaction between the default mode network and other cognitive networks.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
2.5
作者：
Kobayashi, Yasushi;Amaral, David G.
通讯作者：
Amaral, David G.
影响因子：
5.7
作者：
Hampson, Michelle;Tokoglu, Fuyuze;Constable, R. Todd
通讯作者：
Constable, R. Todd