Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics.
Ascaris lumbricoides-induced interleukin-10 is not associated with atopy in schoolchildren in a rural area of the tropics.
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DOI：
10.1086/586904
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发表时间：
2008-05-01
期刊：
影响因子：
--
通讯作者：
Nutman TB
中科院分区：
文献类型：
--
作者：
Cooper PJ;Mitre E;Moncayo AL;Chico ME;Vaca MG;Nutman TB
在流行地区，肠道蠕虫感染可能对过敏原皮肤试验反应性有保护作用，有人认为IL-10可能介导了这种作用。我们研究了IL-10和IL-10+ T细胞群是否可能调节肠道寄生虫流行地区儿童的特应性。对厄瓜多尔农村社区的学龄儿童进行过敏原皮肤试验，评估其对美洲大蠊和翼状棘球蚴的反应性。皮肤试验阳性（n=39）和皮肤试验阴性（n=41）患儿放血，在类蛔虫抗原存在下培养外周血白细胞，测定IL-10蛋白和细胞内表达IL-10的T细胞群频率。我们还研究了这些免疫因素是否影响特异性IgE和皮肤试验对空气过敏原的反应性之间的关系。没有证据表明类麻草诱导的IL-10蛋白或IL-10+ T细胞水平与过敏原皮肤试验反应性之间存在关联。过敏原特异性IgE和皮肤试验反应性之间的关系不受IL-10蛋白水平或IL-10+ T细胞频率的影响。我们的数据不支持IL-10在调节热带肠道蠕虫流行地区儿童的特应性中的作用。
Intestinal helminth infections may protect against allergen skin test reactivity in endemic areas and it has been suggested that IL-10 may mediate this effect. We investigated if IL-10 and populations of IL-10+ T cells may modulate atopy in children living in an endemic area for intestinal helminth parasites. Ecuadorian school children from rural communities were assessed for allergen skin test reactivity to Periplaneta americana and Dermatophagoides pteronyssinus. Skin test positive (n=39) and skin test negative (n=41) children were bled and peripheral blood leukocytes were cultured in the presence of Ascaris lumbricoides antigen to measure IL-10 protein and the frequencies of T cell populations expressing intracellular IL-10. We investigated also if these immunological factors affected the association between specific IgE and skin test reactivity to aeroallergens. There was no evidence of associations between levels of A. lumbricoides-induced IL-10 protein or IL-10+ T cells and allergen skin test reactivity. The association between allergen-specific IgE and skin test reactivity was not affected by levels of IL-10 protein or the frequencies of IL-10+ T cells. Our data do not support a role for IL-10 in modulating atopy in children living in an intestinal helminth-endemic area of the tropics.
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影响因子：
9.4
作者：
Bhattacharyya, T;Santra, A;Chatterjee, BP
通讯作者：
Chatterjee, BP
影响因子：
6.4
作者：
Cooper, PJ;Chico, ME;Nutman, TB
通讯作者：
Nutman, TB
影响因子：
14.2
作者：
Borish, L;Aarons, A;Wenzel, S
通讯作者：
Wenzel, S
影响因子：
14.2
作者：
VANDERZEE, JS;DEGROOT, H;AALBERSE, RC
通讯作者：
AALBERSE, RC
影响因子：
56.9
作者：
Hori, S;Nomura, T;Sakaguchi, S
通讯作者：
Sakaguchi, S