Host responses to mucosal biofilms in the lung and gut.
Host responses to mucosal biofilms in the lung and gut.
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DOI：
10.1038/s41385-020-0270-1
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发表时间：
2020-05
影响因子：
8
通讯作者：
Sears CL
中科院分区：
文献类型：
--
作者：
Domingue JC;Drewes JL;Merlo CA;Housseau F;Sears CL
人体微生物组对健康和疾病的影响至关重要，近年来已得到深入研究。微生物促进免疫系统发育，对宿主营养物质的产生和吸收至关重要，但也与疾病的发病机制有关。特别地，细菌生物膜长期以来被认为是人类慢性感染和疾病的贡献者。然而，我们对宿主如何对生物膜的存在做出反应，特别是对生物膜的免疫反应，以及这如何有助于疾病发病机制的理解是有限的。这篇综述的目的是突出什么是已知的生物膜形成和生物膜研究的体内模型。我们评论的贡献，生物膜对人类疾病，重点是肺部疾病，囊性纤维化和慢性阻塞性肺疾病，肠道疾病，炎症性肠病和结直肠癌。
The impact of the human microbiome on health and disease is of utmost importance and has been studied intensively in recent years. Microbes promote immune system development and are essential to the production and absorption of nutrients for the host but are also implicated in disease pathogenesis. Particularly, bacterial biofilms have long been recognized as contributors to chronic infections and diseases in humans. However, our understanding of how the host responds to the presence of biofilms, specifically the immune response to biofilms, and how this contributes to disease pathogenesis is limited. This review aims to highlight what is known about biofilm formation and in vivo models available for the biofilm study. We critique the contribution of biofilms to human diseases, focusing on the lung diseases, cystic fibrosis and chronic obstructive pulmonary disease, and the gut diseases, inflammatory bowel disease and colorectal cancer.
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影响因子：
6.7
作者：
Ashkar AA;Mossman KL;Coombes BK;Gyles CL;Mackenzie R
通讯作者：
Mackenzie R
影响因子：
3.2
作者：
DEVRIES, CA;OHMAN, DE
通讯作者：
OHMAN, DE
影响因子：
3.7
作者：
Erb-Downward JR;Thompson DL;Han MK;Freeman CM;McCloskey L;Schmidt LA;Young VB;Toews GB;Curtis JL;Sundaram B;Martinez FJ;Huffnagle GB
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Huffnagle GB
影响因子：
5.2
作者：
Aanaes, Kasper;Johansen, Helle Krogh;Hoiby, Niels
通讯作者：
Hoiby, Niels
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C