Mild and Moderate Traumatic Brain Injury and Repeated Stress Affect Corticosterone in the Rat.
Mild and Moderate Traumatic Brain Injury and Repeated Stress Affect Corticosterone in the Rat.
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轻度和中度创伤性脑损伤和反复压力会影响大鼠的皮质酮。
DOI：
10.1089/neur.2020.0019
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发表时间：
2020
影响因子：
2.4
通讯作者：
Thomas TC
中科院分区：
文献类型：
--
作者：
Rowe RK;Ortiz JB;Thomas TC
创伤性脑损伤（TBI）幸存者患有一系列疾病，包括创伤后内分泌疾病，这些疾病可能导致患者的身体和精神变化，极大地影响生活质量。本研究验证了以下假设：随着时间的推移，轻度和中度弥漫性TBI会导致皮质酮（CORT）调节的慢性缺陷。使年轻成年雄性大鼠（n = 9-11/组）经受由中线液压冲击损伤（mFPI）或对照假手术诱导的轻度或中度TBI。在6和24小时后，轻度和中度TBI导致升高的静息血浆CORT水平相比，未受伤的假手术。与TBI严重程度无关，所有大鼠在损伤后7、14、28和54天的静息血浆CORT水平均低于术前基线CORT水平。循环水平的CORT也进行了评价约束压力和地塞米松（DEX），合成糖皮质激素的反应。独立于TBI的严重程度，束缚应激升高CORT在30，60和90分钟后的应激源开始在所有的损伤后的时间点。与损伤后7天（DPI）相比，在28天和54天的束缚后观察到对束缚应激的钝化CORT反应，CORT水平较低，表明对应激源的习惯化。与低剂量DEX相比，高剂量DEX在束缚应激开始后90分钟降低CORT水平，与TBI严重程度无关。这些结果支持TBI诱导的CORT失调在急性时间点，但额外的研究，调查内分泌疾病的发病和进展，控制习惯反复约束压力，需要告知TBI幸存者的这种发病率的诊断和治疗。
Traumatic brain injury (TBI) survivors suffer from a range of morbidities, including post-traumatic endocrinopathies that can cause physical and mental changes in patients, greatly compromising quality of life. This study tested the hypothesis that mild and moderate diffuse TBI leads to chronic deficiencies in corticosterone (CORT) regulation following repeated exposure to restraint stress over time. Young adult male rats (n = 9–11/group) were subjected to mild or moderate TBI induced by midline fluid percussion injury (mFPI) or control sham surgery. At 6 and 24 h post-injury, both mild and moderate TBI resulted in elevated resting plasma CORT levels compared with uninjured shams. Independent of TBI severity, all rats had lower resting plasma CORT levels at 7, 14, 28, and 54 days post-injury compared with pre-surgery baseline CORT. Circulating levels of CORT were also evaluated under restraint stress and in response to dexamethasone (DEX), a synthetic glucocorticoid. Independent of TBI severity, restraint stress elevated CORT at 30, 60, and 90 min post-stressor initiation at all post-injury time-points. A blunted CORT response to restraint stress was observed with lower CORT levels after restraint at 28 and 54 days compared with 7 days post-injury (DPI), indicative of habituation to the stressor. A high dose of DEX lowered CORT levels at 90 min post-restraint stress initiation compared with low-dose DEX, independent of TBI severity. These results support TBI-induced CORT dysregulation at acute time-points, but additional studies that investigate the onset and progression of endocrinopathies, controlling for habituation to repeated restraint stress, are needed to inform the diagnosis and treatment of such morbidities in TBI survivors.
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影响因子：
--
作者：
CRITCHLOW, V;BARSELA, M;LIPSCOMB, HS
通讯作者：
LIPSCOMB, HS
DOI：
10.12703/p5-13
发表时间：
2013-01-01
期刊：
F1000prime reports
影响因子：
--
作者：
Karatsoreos, Ilia N;McEwen, Bruce S
通讯作者：
McEwen, Bruce S
DOI：
10.1249/mss.0b013e31819fcd1b
发表时间：
2009-09-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Hosseini, Ario H.;Lifshitz, Jonathan
通讯作者：
Lifshitz, Jonathan
影响因子：
10.3
作者：
Barriga, C;Martín, MI;Rodríguez, AB
通讯作者：
Rodríguez, AB
影响因子：
4.1
作者：
Dhabhar, FS;McEwen, BS;Spencer, RL
通讯作者：
Spencer, RL