Building a retinal mosaic: cell-fate decision in the fly eye.
Building a retinal mosaic: cell-fate decision in the fly eye.
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构建视网膜镶嵌:果蝇眼中的细胞命运决定。
DOI:
10.1016/j.tcb.2004.09.007
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发表时间:
2004
期刊:
影响因子:
--
通讯作者:
Desplan,Claude
中科院分区:
文献类型:
--
作者:
Wernet,MathiasF;Desplan,Claude
Across the animal kingdom, color discrimination is achieved by comparing the outputs of photoreceptor cells (PRs) that have different spectral sensitivities. Much remains to be understood about how the pattern of these different PRs is generated and maintained. TheDrosophilaeye has long provided a beautiful system for understanding various aspects of retinal-cell differentiation. Recent progress in this field is revealing that a highly ordered series of events, involving cell–cell communication, localized signaling and stochastic choices, creates a complex mosaic of PRs that is reminiscent of the human retina. Notably, several of the factors used in generating the retinal mosaic of the fruitfly have corresponding functions in vertebrates that are likely to have similar roles.
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