Advances in microRNAs: implications for immunity and inflammatory diseases.
Advances in microRNAs: implications for immunity and inflammatory diseases.
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DOI：
10.1111/j.1582-4934.2008.00534.x
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发表时间：
2009-01
影响因子：
5.3
通讯作者：
Pivarcsi A
中科院分区：
文献类型：
--
作者：
Sonkoly E;Pivarcsi A
自1993年发现microRNA以来，microRNA（miRNAs）参与了许多生物学过程，包括发育、分化、增殖和凋亡。miRNA的功能是通过序列特异性靶向mRNA来控制细胞中的蛋白质产生，以进行翻译抑制或mRNA降解。有趣的是，与人类基因组的平均值相比，免疫基因显然优先被miRNA靶向，这表明miRNA介导的调节对正常免疫应答的重要性。本文就miRN在慢性炎症性皮肤病、自身免疫和病毒感染等免疫相关疾病发病机制中的作用进行综述。
Since their discovery in 1993 and the introduction of the term microRNA in 2001, it has become evident that microRNAs (miRNAs) involved in many biological processes, including development, differentiation, proliferation and apoptosis. The function of miRNA the control of protein production in cells by sequence-specific targeting of mRNAs for translational repression or mRNA degradati Interestingly, immune genes are apparently preferentially targeted by miRNAs compared to the average of the human genome, indicat the significance of miRNA-mediated regulation for normal immune responses. Here, we review what is known about the role of miRN in the pathogenesis of immune-related diseases such as chronic inflammatory skin diseases, autoimmunity and viral infections.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
7.8
作者：
Grosshans, Helge;Slack, Frank J
通讯作者：
Slack, Frank J
影响因子：
2.6
作者：
Dai, Y.;Huang, Y-S;Yin, Y-B
通讯作者：
Yin, Y-B
影响因子：
4.5
作者：
Cai, XZ;Hagedorn, CH;Cullen, BR
通讯作者：
Cullen, BR
影响因子：
56.9
作者：
Farh, KKH;Grimson, A;Bartel, DP
通讯作者：
Bartel, DP