A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors.
A Pancancer Study of PIEZO1 as a Prognosis and Immune Biomarker of Human Tumors.
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PIEZO1 作为人类肿瘤的预后和免疫生物标志物的泛癌研究
DOI：
10.1155/2022/6725570
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发表时间：
2022
影响因子：
--
通讯作者：
Yao, Xin
中科院分区：
文献类型：
--
作者：
Wu, Yunhui;Zhang, Jingying;Hou, Can;Wang, Hongyu;Zhu, Min;Yao, Xin
PIEZO1是一种机械敏感的离子通道蛋白，已被发现与多种癌症相关。然而，目前对PIEZO1的系统泛癌研究还很缺乏。我们在33种类型的癌症中检测了PIEZO1，首次探索了它在预后和免疫功能中的作用。基于开放数据库TCGA、GTEx和CPTAC，PIEZO1已被证明在大多数癌症组织中与邻近正常组织相比差异表达。用GEPIA2分析PIEZO1与肿瘤患者预后的相关性。PIEZO1在TCGA肿瘤中的基因改变表明，在某些肿瘤中，突变是与OS、DSS、DFS和PFS相关的改变。根据CPTAC数据集，在一些癌症中检测到了蛋白质磷酸化水平的变化。PIEZO1的表达与免疫细胞的浸润有关，如内皮细胞和癌相关成纤维细胞。最后，用KEGG和GO富集法研究了PIEZO1的分子机理。我们的第一个泛癌分析说明了PIEZO1在不同类型的肿瘤中的作用。
PIEZO1, a mechanosensitive ion channel protein, has been identified in the correlation between several cancers. However, the systematic pancancer study of PIEZO1 still lacks. We examined PIEZO1 across thirty-three types of cancers to explore its role in prognosis and immunological function for the first time. Based on the open databases TCGA, GTEx and CPTAC, PIEZO1 has been demonstrated to be differentially expressed in most cancers compared to adjacent normal tissues. The distinct correlation between PIEZO1 and prognosis of tumor patients was explored by GEPIA2. Genetic alteration of PIEZO1 in the TCGA tumors showed that mutation is the alteration which is linked to OS, DSS, DFS and PFS in some tumors. Alterations of protein phosphorylation levels were detected in some cancers based on the CPTAC dataset. PIEZO1 expression was linked with immune cell infiltration, such as endothelial cell and cancer-associated fibroblast. Finally, KEGG and GO enrichment analyses were applied to investigate the molecular mechanism of PIEZO1. Our first pancancer analysis illustrated the roles of PIEZO1 in different types of tumors.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
4.4
作者：
Liu, Chinky Shiu Chen;Raychaudhuri, Deblina;Ganguly, Dipyaman
通讯作者：
Ganguly, Dipyaman
影响因子：
7.3
作者：
Liu H;Hu J;Zheng Q;Feng X;Zhan F;Wang X;Xu G;Hua F
通讯作者：
Hua F
由机械敏感离子通道 PIEZO1 和组织力学介导的前馈机制促进胶质瘤侵袭。
影响因子：
16.2
作者：
Chen, Xin;Wanggou, Siyi;Huang, Xi
通讯作者：
Huang, Xi
影响因子：
4.7
作者：
Liu C;Zhou X;Zeng H;Wu D;Liu L
通讯作者：
Liu L