Established and emerging markers of kidney function.
Established and emerging markers of kidney function.
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DOI：
10.1373/clinchem.2011.167494
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发表时间：
2012-04
影响因子：
9.3
通讯作者：
Waikar SS
中科院分区：
文献类型：
--
作者：
Ferguson MA;Waikar SS
肾脏执行多种维持体内平衡的基本功能。在临床医学中，肾小球滤过率（GFR）提供了整体肾功能的最佳指标，蛋白尿增加了肾脏和非肾脏预后的额外信息。一些新的肾损伤和功能的生物标志物正在研究中。血浆肌酸酐浓度是用于估计GFR的最广泛使用的测量。血浆半胱氨酸蛋白酶抑制剂C和β-微量蛋白可能最终被证明上级肌酐。GFR可以通过使用外源性滤过标志物直接测量，尽管它们的作用主要限于研究环境。通过使用荧光标记的标记物实时，无创测量GFR可能在未来可用。新的肾小管损伤生物标志物，如中性粒细胞明胶酶相关脂质运载蛋白、肾损伤分子-1、肝型脂肪酸结合蛋白、N-乙酰基-β-（D）-氨基葡萄糖苷酶和白细胞介素-18，可在GFR变化之前或不变化的情况下早期检测急性肾损伤。有多种方法可用于协助临床医生评估肾功能和损伤。正在进行的研究将有助于确定几种新标记物的效用，并阐明它们在肾脏疾病患者和有肾脏疾病风险患者的护理中的作用。
The kidney performs a multitude of essential functions to maintain homeostasis. In clinical medicine, glomerular filtration rate (GFR) provides the best index of overall kidney function, and protein-uria adds additional information on renal and nonrenal prognosis. Several novel biomarkers of kidney injury and function are under investigation. Plasma creatinine concentration is the most widely used measure for estimation of GFR. Plasma cystatin C and β-trace protein may eventually prove to be superior to creatinine. GFR may be measured directly by use of exogenous filtration markers, although their role is primarily limited to the research setting. Real-time, noninvasive measurement of GFR by using fluorescently labeled markers may be available in the future. Novel biomarkers of tubular injury such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, liver-type fatty acid binding protein, N-acetyl-β-(D)-glucosaminidase, and interleukin-18 may enable the early detection of acute kidney injury before or in the absence of a change in GFR. A variety of methods are available to assist clinicians in the assessment of kidney function and injury. Ongoing investigation will help determine the utility of several new markers and clarify their role in the care of patients with and at risk for kidney disease.
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影响因子：
2.8
作者：
Abbink, Floor C. H.;Laarrnan, Celeste A. R. C.;Bokenkamp, Arend
通讯作者：
Bokenkamp, Arend
影响因子：
2.8
作者：
Boekenkamp, Arend;Franke, Ingo;Stoffel-Wagner, Birgit
通讯作者：
Stoffel-Wagner, Birgit
影响因子：
6.8
作者：
Grubb, Anders;Blirup-Jensen, Soren;Zegers, Ingrid
通讯作者：
Zegers, Ingrid
影响因子：
158.5
作者：
Grantham, JJ;Torres, VE;Miller, JP
通讯作者：
Miller, JP
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)