Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.
Type 2 diabetes and cognitive impairment in an older population with overweight or obesity and metabolic syndrome: baseline cross-sectional analysis of the PREDIMED-plus study.
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DOI：
10.1038/s41598-018-33843-8
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发表时间：
2018-10-31
影响因子：
4.6
通讯作者：
Fernández-Aranda F
中科院分区：
文献类型：
--
作者：
Mallorquí-Bagué N;Lozano-Madrid M;Toledo E;Corella D;Salas-Salvadó J;Cuenca-Royo A;Vioque J;Romaguera D;Martínez JA;Wärnberg J;López-Miranda J;Estruch R;Bueno-Cavanillas A;Alonso-Gómez Á;Tur JA;Tinahones FJ;Serra-Majem L;Martín V;Lapetra J;Vázquez C;Pintó X;Vidal J;Daimiel L;Gaforio JJ;Matía P;Ros E;Granero R;Buil-Cosiales P;Barragán R;Bulló M;Castañer O;García-de-la-Hera M;Yáñez AM;Abete I;García-Ríos A;Ruiz-Canela M;Díaz-López A;Jiménez-Murcia S;Martínez-González MA;De la Torre R;Fernández-Aranda F
这项研究对老年人群进行了横断面调查：(a) 2 型糖尿病与执行功能 (EF) 的关联； (b) BMI 对 2 型糖尿病和 EF 的影响； (c) 2 型糖尿病中血糖控制与 EF 之间的关联。参与 PREDIMED-PLUS 研究的 6823 名患有超重/肥胖和代谢综合征的老年人接受了一系列认知测试和医学访谈的评估。方差分析显示，与非糖尿病个体相比，2 型糖尿病个体的 EF 表现明显较差。显示了两个互补模型：（1）在整个样本中，2型糖尿病、抑郁症状和BMI的存在对EF有直接的负面影响，而呼吸暂停对EF有间接的负面影响； (2) 在糖尿病子样本中，病程较长与 EF 表现较差相关。与 HbA1c≥53mmol/mol 的参与者相比，HbA1c<53mmol/mol 的 2 型糖尿病参与者表现出更好的认知能力。我们的结果提供了一个受控的综合模型，整合了 2 型糖尿病的相关神经心理和身体变量。该模型表明，一旦诊断出糖尿病，为了提高治疗依从性和生活质量，需要在监测抑郁症状、体重指数和血糖控制的同时实施认知能力下降预防策略。
This study cross-sectionally examines in the elderly population: (a) the association of type 2 diabetes with executive function (EF); (b) the effect of BMI on both type 2 diabetes and EF; (c) the association between glycaemia control and EF in type 2 diabetes. 6823 older individuals with overweight/obesity and metabolic syndrome participating in the PREDIMED-PLUS study, were assessed with a battery of cognitive tests and a medical interview. ANOVA showed a significantly worse performance on EF in type 2 diabetes vs. non-diabetic individuals. Two complementary models were displayed: (1) in the whole sample, the presence of type 2 diabetes, depressive symptoms and BMI had a direct negative effect on EF, while apnoea had an indirect negative effect; (2) in the diabetes subsample, higher illness duration was associated with worse performance in EF. Participants with type 2 diabetes and HbA1c<53 mmol/mol displayed better cognitive performance when compared to those with HbA1c≥53 mmol/mol. Our results provide a controlled comprehensive model that integrates relevant neuropsychological and physical variables in type 2 diabetes. The model suggests that, to improve treatment adherence and quality of life once diabetes has been diagnosed, cognitive decline prevention strategies need to be implemented while monitoring depressive symptoms, BMI and glycaemia control.
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影响因子：
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Kanaya, AM;Barrett-Connor, E;Yaffe, K
通讯作者：
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