Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy.
Pro- and anti-inflammatory cytokine balance in major depression: effect of sertraline therapy.
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DOI：
10.1155/2007/76396
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发表时间：
2007
影响因子：
--
通讯作者：
Sengul A
中科院分区：
文献类型：
--
作者：
Sutcigil L;Oktenli C;Musabak U;Bozkurt A;Cansever A;Uzun O;Sanisoglu SY;Yesilova Z;Ozmenler N;Ozsahin A;Sengul A
抗抑郁治疗与细胞因子水平变化之间的具体联系仍有待阐明。本研究旨在探讨IL-2、IL-4、IL-12、肿瘤坏死因子-1、转化生长因子-1、单核细胞趋化蛋白-1在抑郁症发病中的作用及舍曲林的治疗作用。在入院时和舍曲林治疗8周后测定细胞因子和趋化因子水平。结果表明，抑郁症患者的促炎性细胞因子(IL-2、IL-12、TNF-1)和单核细胞趋化蛋白-1(MCP-1)显著高于正常对照组，而抗炎性细胞因子(IL-4和TGF-1)显著低于正常对照组。提示舍曲林治疗可能通过降低促炎细胞因子IL-12，增加抗炎细胞因子IL-4和TGF-1发挥免疫调节作用。综上所述，我们的结果表明抑郁症患者的Th1、Th2和Th3型细胞因子发生了改变，其中一些可能已被舍曲林治疗纠正。
The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-, TGF-1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF-) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF-1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF-1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment.
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