Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.
Key Genes Regulating Skeletal Muscle Development and Growth in Farm Animals.
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DOI：
10.3390/ani11030835
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发表时间：
2021-03-16
期刊：
影响因子：
--
通讯作者：
Guo W
中科院分区：
文献类型：
--
作者：
Mohammadabadi M;Bordbar F;Jensen J;Du M;Guo W
骨骼肌质量是一个重要的经济性状，肌肉的发育和生长是为人类消费提供足够肉类的关键因素。因此，了解调控骨骼肌发育的（候选）基因对于了解肌肉生长的分子遗传调控至关重要，并且可以使肉类工业朝着增加肉类产量的目标受益。在过去的几年里，我们在理解这些机制方面取得了重大进展，因此，我们决定撰写一篇全面的综述，涵盖对农场动物肌肉发育和生长至关重要的调控因子和（候选）基因。这些基因和因子的检测增加了我们对肌肉生长和发育的理解，对育种者满足全球范围内的肉类生产需求有很大帮助。 农场动物物种在满足全球范围内的肉类需求方面发挥着至关重要的作用，它们正在进行基因开发，以提高肉类生产的效率。特别是，重要的育种目标之一是增加农场动物的骨骼肌生长。肌肉发育和生长的增强对于满足消费者对肉品质的需求至关重要。胎儿骨骼肌发育涉及肌发生（伴随成肌细胞增殖、分化和融合）、纤维形成和脂肪形成。通常，肌生成受内在和外在因素的复杂网络调节，所述内在和外在因素由肌生成调节因子基因在两个或三个阶段中以及编码激酶的基因监测。标记辅助选择依赖于与肌肉发育正相关或负相关的候选基因，可以作为家畜经典选择策略的有力补充。这篇全面的综述涵盖了调节农场动物（牛，羊，鸡和猪）肌肉发育和生长的重要（候选）基因。这些基因的鉴定是朝着提高肉产量和改善肉品质的目标迈出的重要一步。
Skeletal muscle mass is an important economic trait, and muscle development and growth is a crucial factor to supply enough meat for human consumption. Thus, understanding (candidate) genes regulating skeletal muscle development is crucial for understanding molecular genetic regulation of muscle growth and can be benefit the meat industry toward the goal of increasing meat yields. During the past years, significant progress has been made for understanding these mechanisms, and thus, we decided to write a comprehensive review covering regulators and (candidate) genes crucial for muscle development and growth in farm animals. Detection of these genes and factors increases our understanding of muscle growth and development and is a great help for breeders to satisfy demands for meat production on a global scale. Farm-animal species play crucial roles in satisfying demands for meat on a global scale, and they are genetically being developed to enhance the efficiency of meat production. In particular, one of the important breeders’ aims is to increase skeletal muscle growth in farm animals. The enhancement of muscle development and growth is crucial to meet consumers’ demands regarding meat quality. Fetal skeletal muscle development involves myogenesis (with myoblast proliferation, differentiation, and fusion), fibrogenesis, and adipogenesis. Typically, myogenesis is regulated by a convoluted network of intrinsic and extrinsic factors monitored by myogenic regulatory factor genes in two or three phases, as well as genes that code for kinases. Marker-assisted selection relies on candidate genes related positively or negatively to muscle development and can be a strong supplement to classical selection strategies in farm animals. This comprehensive review covers important (candidate) genes that regulate muscle development and growth in farm animals (cattle, sheep, chicken, and pig). The identification of these genes is an important step toward the goal of increasing meat yields and improves meat quality.
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影响因子：
64.5
作者：
ARBER, S;HALDER, G;CARONI, P
通讯作者：
CARONI, P
影响因子：
4.1
作者：
Cockett, NE;Smit, MA;Charlier, C
通讯作者：
Charlier, C
影响因子：
8.5
作者：
Bordbar F;Jensen J;Du M;Abied A;Guo W;Xu L;Gao H;Zhang L;Li J
通讯作者：
Li J
影响因子：
0.4
作者：
Bagatoli, A.;Gasparino, E.;Del Vesco, A. P.
通讯作者：
Del Vesco, A. P.
影响因子：
16
作者：
Bergstrom, DA;Penn, BH;Tapscott, SJ
通讯作者：
Tapscott, SJ