Atypical neural responses during face processing in female adolescents with conduct disorder.
Atypical neural responses during face processing in female adolescents with conduct disorder.
复制标题
DOI：
10.1016/j.jaac.2014.02.009
复制
发表时间：
2014-06
影响因子：
13.3
通讯作者：
Calder, Andrew J.
中科院分区：
文献类型：
--
作者：
Fairchild, Graeme;Hagan, Cindy C.;Passamonti, Luca;Walsh, Nicholas D.;Goodyer, Ian M.;Calder, Andrew J.
女性行为障碍（CD）与成年后的负面结果有关，包括心理健康问题和人格障碍。虽然最近的神经影像学研究报告的变化，面部情绪处理过程中的神经活动在男性与CD或冷酷无情（CU）的特质，一直没有神经影像学研究，特别是评估女性与CD。我们通过调查CD女性青少年在处理情绪或中性面孔时是否表现出非典型神经激活来解决这一差距。我们从20名患有CD的女性青少年和20名女性对照参与者中获得了功能性磁共振成像（fMRI）数据，同时他们看到了愤怒，悲伤和中性的面孔。综合组（CD，对照组）通过面部情绪（愤怒、悲伤、中性）方差分析（ANOVA）揭示了面部情绪在上级颞叶皮质、梭状回、腹外侧前额叶皮质和脑岛中的主要影响，以及组在内侧眶额皮质（OFC）和右前脑岛中的主要影响。与健康对照组相比，CD女性受试者的内侧OFC减少，前部OFC反应增加。没有显著的组×面部情绪交互。终生CD症状与杏仁核、上级颞叶皮层、梭状回和背外侧前额叶皮层活动呈负相关。CU特征呈负相关，梭状回活动的对比悲伤与中性的面孔。女性与CD表现出非典型的神经激活过程中的所有面部表情的处理，无论效价。我们的研究结果表明，严重的CD症状和CU性状是重要的，在解释异常模式的神经活动。
Conduct disorder (CD) in females is associated with negative adult outcomes including mental health problems and personality disorders. Although recent neuroimaging studies have reported changes in neural activity during facial emotion processing in males with CD or callous-unemotional (CU) traits, there have been no neuroimaging studies specifically assessing females with CD. We addressed this gap by investigating whether female adolescents with CD show atypical neural activation when processing emotional or neutral faces. We acquired functional magnetic resonance imaging (fMRI) data from 20 female adolescents with CD and 20 female control participants while they viewed angry, sad, and neutral faces. An omnibus group (CD, control) by facial emotion (angry, sad, neutral) analysis of variance (ANOVA) revealed main effects of facial emotion in superior temporal cortex, fusiform gyrus, ventrolateral prefrontal cortex and insula, and main effects of group in medial orbitofrontal cortex (OFC) and right anterior insula. Female participants with CD showed reduced medial OFC and increased anterior insula responses relative to healthy controls. There were no significant group × facial emotion interactions. Lifetime CD symptoms were negatively correlated with amygdala, superior temporal cortex, fusiform gyrus, and dorsolateral prefrontal cortex activity for the contrast “all-faces versus fixation.” CU traits were negatively correlated with fusiform gyrus activity for the contrast sad versus neutral faces. Females with CD showed atypical neural activation during the processing of all facial expressions, irrespective of valence. Our results demonstrate that severity of CD symptoms and CU traits is important in explaining abnormal patterns of neural activity.
登录
查看更多内容
影响因子：
10.6
作者：
Fairchild, Graeme;Stobbe, Yvette;van Goozen, Stephanie H. M.;Calder, Andrew J.;Goodyer, Ian M.
通讯作者：
Goodyer, Ian M.
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
DOI：
10.1111/j.1469-7610.2008.02020.x
发表时间：
2009-05
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
--
作者：
Fairchild G;Van Goozen SH;Calder AJ;Stollery SJ;Goodyer IM
通讯作者：
Goodyer IM
影响因子：
3.8
作者：
Essau, Cecilia A.;Sasagawa, Satoko;Frick, Paul J.
通讯作者：
Frick, Paul J.
影响因子：
--
作者：
Finger, Elizabeth C.;Marsh, Abigail A.;Blair, James R.
通讯作者：
Blair, James R.