No difference in serum leptin concentrations between urban‐dwelling Austronesians and Non‐Austronesians in Papua New Guinea
No difference in serum leptin concentrations between urban‐dwelling Austronesians and Non‐Austronesians in Papua New Guinea
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巴布亚新几内亚城市居住的南岛人与非南岛人之间的血清瘦素浓度没有差异
DOI：
10.1002/ajhb.20445
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发表时间：
2005
影响因子：
2.9
通讯作者：
R. Ohtsuka
中科院分区：
文献类型：
--
作者：
Mika Tanaka;M. Umezaki;K. Natsuhara;T. Yamauchi;T. Inaoka;T. Hongo;M. Nagano;C. Watanabe;R. Ohtsuka
太平洋岛屿人口可以大致分为南岛人（AN）和非南岛人（NAN）;肥胖和2型糖尿病在前者中很普遍，尽管这两个群体的瘦素水平很少被调查。选择了37对（20男17女）成年人，年龄和体脂百分比匹配，来自说AN语的Balopa和说NAN语的Huli，所有人都迁移到巴布亚新几内亚首都莫尔兹比港定居，用于比较他们的血清瘦素浓度。巴洛帕人与胡里人在年龄上没有显著差异（男性分别为30.5 ± 9.7和30.0 ± 8.7岁，女性分别为33.7 ± 8.9和34.1 ± 7.5岁）或体脂百分比（男性19.4 ± 5.6和18.8 ± 4.6，女性34.1 ± 6.2和33.3 ± 5.0），但巴洛帕族女性BMI（26.4 ± 4.9）低于胡里族（29.7 ± 4.7）（P = 0.02）。在两个种族中，女性的瘦素浓度明显高于男性，但在控制生活方式因素和血脂后，男性（3.5 ± 2.6和3.1 ± 4.7 ng/ml，P = 0.14）或女性（22.7 ± 12.9和19.7 ± 11.9 ng/ml，P = 0.40）的组间差异无统计学意义。多元回归分析显示，瘦素浓度的显著预测因子是体脂百分比（β = 0.58）、性别（男性，0;女性，1; β = 0.27）和吸烟状态（非吸烟者，0;吸烟者，1; β =-0.15）（R2 = 0.80），这意味着瘦素浓度主要由生活方式导致的体脂决定。总之，NAN人群与AN人群的瘦素状态没有内源性差异，AN人群被认为是具有“节俭”基因型的典型群体。Am. J.哈姆。17：696-703，2005.© 2005 Wiley利斯公司
Pacific Islands populations can be broadly divided into Austronesians (AN) and Non‐Austronesians (NAN); obesity and type 2 diabetes are prevalent in the former, although leptin levels in both groups have seldom been investigated. Thirty‐seven (20 male and 17 female) adult pairs, matched by age and percent body fat, from AN‐speaking Balopa and NAN‐speaking Huli, all of whom migrated to settle in Port Moresby, the capital of Papua New Guinea, were selected for comparison of their serum leptin concentrations. The Balopa did not differ significantly from the Huli in age (30.5 ± 9.7 and 30.0 ± 8.7 years for males, 33.7 ± 8.9 and 34.1 ± 7.5 years for females, respectively) or percent body fat (19.4 ± 5.6 and 18.8 ± 4.6 for males, 34.1 ± 6.2 and 33.3 ± 5.0 for females), although the BMI of females was lower in the Balopa (26.4 ± 4.9) than in the Huli (29.7 ± 4.7) (P = 0.02). In both ethnic groups, females had markedly higher leptin concentrations than males, but there was no significant inter‐group difference in males (3.5 ± 2.6 and 3.1 ± 4.7 ng/ml, P = 0.14) or females (22.7 ± 12.9 and 19.7 ± 11.9 ng/ml, P = 0.40), after controlling for lifestyle factors and serum lipids. Multiple regression analysis revealed that significant predictors of leptin concentration were % body fat (β = 0.58), sex (male, 0; female, 1; β = 0.27), and smoker status (non‐smoker, 0; smoker, 1; β = −0.15) (R2 = 0.80), implying that the leptin concentration was primarily determined by lifestyle‐derived body fatness. In conclusion, the NAN populations do not endogenously differ in leptin status from the AN populations, who have been recognized as a typical group with a “thrifty” genotype. Am. J. Hum. Biol. 17:696–703, 2005. © 2005 Wiley‐Liss, Inc.
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DOI：
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期刊：
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