Rhythmic movement in Parkinson's disease: effects of visual feedback and medication state.
Rhythmic movement in Parkinson's disease: effects of visual feedback and medication state.
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DOI：
10.1007/s00221-011-2685-0
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发表时间：
2011-06
影响因子：
2
通讯作者：
Poizner, H.
中科院分区：
文献类型：
--
作者：
Levy-Tzedek, S.;Krebs, H. I.;Arle, J. E.;Shils, J. L.;Poizner, H.
关键词：
先前对帕金森氏病(PD)患者离散运动的研究发现，除了执行比对照组参与者慢的动作外，他们还表现出运动协调和感觉运动整合方面的特定缺陷，这是准确指导运动所需的。服用药物后，运动速度恢复正常，但运动的协调方面没有恢复正常。这导致了一种假设，即多巴胺能药物更容易补偿密集的运动方面(如速度)，而不是协调方面(如不同肢体节段的协调)(Schettino等，Exp Brain Res 168：186-202,2006)。我们在前臂有节奏的连续运动上测试了这一假说。在我们的任务中，目标峰值速度和幅度、视觉反馈的可用性和药物状态(开/关)是不同的。我们发现，与离散运动的结果一致，药物可以使峰值速度(强度方面)正常化，而需要速度和幅度调制(协调方面)协调的准确性却不能通过多巴胺能治疗而正常化。然而，我们的研究发现，运动的一个密集方面的幅度也没有被药物正常化，这表明简单的通路增益增加并不能在相同程度上补救所有密集的运动方面。在归一化运动峰值速度的同时，也没有归一化运动幅度。此外，我们发现，当视觉反馈不可用时，所有参与者(PD和对照组)都会做出更快的动作。多巴胺能药物和视觉反馈的有效性对运动速度的影响是相加的。PD组和对照组的运动速度一致增加的发现表明，视觉反馈可能是校准峰值速度所必需的，否则被运动控制系统低估了。
Previous studies examining discrete movements of Parkinson’s disease (PD) patients have found that in addition to performing movements that were slower than those of control participants, they exhibit specific deficits in movement coordination and in sensorimotor integration required to accurately guide movements. With medication, movement speed was normalized, but the coordinative aspects of movement were not. This led to the hypothesis that dopaminergic medication more readily compensates for intensive aspects of movement (such as speed), than for coordinative aspects (such as coordination of different limb segments) (Schettino et al., Exp Brain Res 168:186–202, 2006). We tested this hypothesis on rhythmic, continuous movements of the forearm. In our task, target peak speed and amplitude, availability of visual feedback, and medication state (on/off) were varied. We found, consistent with the discrete-movement results, that peak speed (intensive aspect) was normalized by medication, while accuracy, which required coordination of speed and amplitude modulation (coordinative aspect), was not normalized by dopaminergic treatment. However, our findings that amplitude, an intensive aspect of movement, was also not normalized by medication, suggests that a simple pathway gain increase does not act to remediate all intensive aspects of movement to the same extent. While it normalized movement peak speed, it did not normalize movement amplitude. Furthermore, we found that when visual feedback was not available, all participants (PD and controls) made faster movements. The effects of dopaminergic medication and availability of visual feedback on movement speed were additive. The finding that movement speed uniformly increased both in the PD and the control groups suggests that visual feedback may be necessary for calibration of peak speed, otherwise underestimated by the motor control system.
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影响因子：
2.5
作者：
Doeringer, JA;Hogan, N
通讯作者：
Hogan, N
DOI：
10.1176/appi.neuropsych.18.3.402
发表时间：
2006-06-01
影响因子：
2.9
作者：
Holroyd, Suzanne;Wooten, G. Frederick
通讯作者：
Wooten, G. Frederick
影响因子：
14.5
作者：
FLOWERS, K
通讯作者：
FLOWERS, K
影响因子：
14.5
作者：
Fellows, SJ;Noth, J;Schwarz, M
通讯作者：
Schwarz, M
影响因子：
--
作者：
Jobst, EE;Melnick, ME;Aminoff, MJ
通讯作者：
Aminoff, MJ