Causal dynamics and information flow in parietal-temporal-hippocampal circuits during mental arithmetic revealed by high-temporal resolution human intracranial EEG.
Causal dynamics and information flow in parietal-temporal-hippocampal circuits during mental arithmetic revealed by high-temporal resolution human intracranial EEG.
复制标题
DOI：
10.1016/j.cortex.2021.11.012
复制
发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Menon V
中科院分区：
文献类型：
--
作者：
Das A;Menon V
心算涉及跨越顶叶和颞叶皮层的分布大脑区域，但对连接它们的因果功能回路的神经动力学知之甚少。在这里，我们使用高时间分辨率（1000赫兹采样率）颅内脑电图从35名参与者，362个电极，1727对电极，研究动态因果电路连接后顶叶皮层（PPC）与腹侧颞枕皮质和海马区域构成的心算的知觉，视觉空间和记忆的构建模块。能够捕获信息流的非线性相位转移熵测量确定背侧PPC是心算过程中的因果流入枢纽，受到腹侧颞枕皮质和海马的梭状回的强烈因果影响。与静息状态和言语记忆回忆相比，在心算过程中，净因果流入量显著高于背侧PPC。我们的分析还揭示了PPC中偶然信号的功能异质性，与腹侧PPC相比，更大的净因果流入PCC背侧。此外，与静息状态和言语记忆回忆相比，在心算过程中，与腹侧相比，背侧、海马体的PPC和腹侧颞枕皮质的因果影响强度显著更高。我们的研究结果为解决数字问题的动态神经回路和中枢提供了新的见解，并揭示了在心算过程中视觉数字形式处理和陈述性记忆系统动态参与PPC的神经生理回路机制。
Mental arithmetic involves distributed brain regions spanning parietal and temporal cortices, yet little is known about the neural dynamics of causal functional circuits that link them. Here we use high-temporal resolution (1000 Hz sampling rate) intracranial EEG from 35 participants, 362 electrodes, and 1727 electrode pairs, to investigate dynamic causal circuits linking posterior parietal cortex (PPC) with ventral temporal-occipital cortex and hippocampal regions which constitute the perceptual, visuospatial, and mnemonic building blocks of mental arithmetic. Nonlinear phase transfer entropy measures capable of capturing information flow identified dorsal PPC as a causal inflow hub during mental arithmetic, with strong causal influences from fusiform gyrus in ventral temporal-occipital cortex as well as the hippocampus. Net causal inflow into dorsal PPC was significantly higher during mental arithmetic, compared to both resting-state and verbal memory recall. Our analysis also revealed functional heterogeneity of casual signaling in the PPC, with greater net causal inflow into the dorsal PCC, compared to ventral PPC. Additionally, the strength of causal influences was significantly higher on dorsal, compared to ventral, PPC from the hippocampus, and ventral temporal-occipital cortex during mental arithmetic, when compared to both resting-state and verbal memory recall. Our findings provide novel insights into dynamic neural circuits and hubs underlying numerical problem solving and reveal neurophysiological circuit mechanisms by which both the visual number form processing and declarative memory systems dynamically engage the PPC during mental arithmetic.
登录
查看更多内容
影响因子：
16.6
作者：
Dastjerdi, Mohammad;Ozker, Muge;Foster, Brett L.;Rangarajan, Vinitha;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
16.6
作者：
Ezzyat Y;Wanda PA;Levy DF;Kadel A;Aka A;Pedisich I;Sperling MR;Sharan AD;Lega BC;Burks A;Gross RE;Inman CS;Jobst BC;Gorenstein MA;Davis KA;Worrell GA;Kucewicz MT;Stein JM;Gorniak R;Das SR;Rizzuto DS;Kahana MJ
通讯作者：
Kahana MJ
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
影响因子：
3.7
作者：
Hermes, Dora;Rangarajan, Vinitha;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
3.3
作者：
Fias, Wim;Mellon, Vinod;Szucs, Denes
通讯作者：
Szucs, Denes