MicroRNA (miRNA) in cancer.

MicroRNA (miRNA) in cancer.
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DOI:
10.1186/s12935-015-0185-1
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发表时间:
2015
影响因子:
5.8
通讯作者:
Reddy KB
Reddy KB
中科院分区:
医学2区
文献类型:
--
作者:
Reddy KB

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近年来,研究人员对研究 mircoRNA (miRNA) 在正常细胞和疾病过程中的作用产生了巨大的兴趣,而且这种兴趣与日俱增。 miRNA 是一类小非编码 RNA,据报道可调节多种癌基因或抑癌基因的表达。 miRNA 的表达谱已经作为诊断和预后生物标志物进入癌症临床,以评估癌症患者肿瘤的发生、进展和治疗反应。本综述总结了:(i) 目前对 miRNA 与其靶基因之间相互作用的理解,(ii) 控制癌发生相关基因表达的调控机制的最新进展,以及 (iii) miRNA 在癌症诊断和治疗中的作用。
In recent years, there has been a tremendous and growing interest among researchers to investigate the role of mircoRNA (miRNA) in normal cellular as well as in disease processes. miRNAs are a family of small non-coding RNAs which were reported to regulate the expression of various oncogenes or tumor suppressor genes. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. This review summarizes: (i) the current understanding of interactions between miRNAs and their target genes, (ii) recent advances in the regulatory mechanisms that control the expression of genes related to carcinogenesis, and (iii) the role of miRNAs in cancer diagnosis and therapy.
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