A combined therapeutic regimen of citalopram and environmental enrichment ameliorates attentional set-shifting performance after brain trauma.
A combined therapeutic regimen of citalopram and environmental enrichment ameliorates attentional set-shifting performance after brain trauma.
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DOI：
10.1016/j.ejphar.2021.174174
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发表时间：
2021-08-05
影响因子：
5
通讯作者：
Bondi CO
中科院分区：
文献类型：
--
作者：
Minchew HM;Radabaugh HL;LaPorte ML;Free KE;Cheng JP;Bondi CO
创伤性脑损伤（TBI）已导致约530万美国患者的持续赤字。针对这些患者的有效疗法仍然稀缺，并且每一项源于实验模型成功的临床试验都失败了。我们认为，失败的部分原因可能是缺乏对广泛影响临床TBI的认知领域的临床前评估。具体来说，TBI文献中的行为任务通常不关注与额叶相关的常见执行障碍，如认知灵活性。在以前的工作中，我们已经证明，注意定势转换测试（AST），一个类似于临床上使用的威斯康星州卡片分类测试（WCST）的任务，可以用来识别认知灵活性障碍后，控制皮质撞击（CCI）损伤。在这项研究中，我们假设，无论是抗抑郁药西酞普兰（CIT）的管理和暴露于临床前模型的神经康复，环境富集（EE），将削弱认知性能缺陷AST单独提供时，并导致更大的好处时，联合使用。成年雄性大鼠进行中度至重度CCI或假损伤。大鼠随机分为实验组，包括手术损伤，药物治疗，和住房条件。我们观察到，CIT和EE单独给药时均提供了显著的认知恢复，并且当联合治疗时，逆转学习表现恢复增加最多（p<0.05）。正在进行的研究继续评估评估大鼠模型中高阶认知TBI相关损伤的临床相关测量的新方法。
Traumatic brain injuries (TBI) have led to lasting deficits for an estimated 5.3 million American patients. Effective therapies for these patients remain scarce and each of the clinical trials stemming from success in experimental models has failed. We believe that the failures may be, in part, due to the lack of preclinical assessment of cognitive domains that widely affect clinical TBI. Specifically, the behavioral tasks in the TBI literature often do not focus on common executive impairments related to the frontal lobe such as cognitive flexibility. In previous work, we have demonstrated that the attentional set-shifting test (AST), a task analogous to the clinically-employed Wisconsin Card Sorting Test (WCST), could be used to identify cognitive flexibility impairments following controlled cortical impact (CCI) injury. In this study, we hypothesized that both the administration of the antidepressant drug citalopram (CIT) and exposure to a preclinical model of neurorehabilitation, environmental enrichment (EE), would attenuate cognitive performance deficits on AST when provided alone and lead to greater benefits when administered in combination. Adult, male rats were subjected to a moderate-severe CCI or sham injury. Rats were randomly divided into experimental groups that included surgical injury, drug therapy, and housing condition. We observed that both CIT and EE provided significant cognitive recovery when administered alone and reversal learning performance recovery increased the most when the therapies were combined (p<0.05). Ongoing studies continue to evaluate novel ways of assessing more clinically relevant measurements of high order cognitive TBI-related impairments in the rat model.
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影响因子：
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作者：
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DOI：
10.1016/j.pnpbp.2010.04.016
发表时间：
2010-08-16
影响因子：
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作者：
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通讯作者：
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