Modulating reconsolidation and extinction to regulate drug reward memory.
Modulating reconsolidation and extinction to regulate drug reward memory.
复制标题
DOI：
10.1111/ejn.14072
复制
发表时间：
2019-08
期刊：
影响因子：
--
通讯作者：
Li JX
中科院分区：
文献类型：
--
作者：
Liu JF;Tian J;Li JX
药物成瘾是一种异常记忆，它与其他记忆共享相同的记忆过程。短暂接触与药物相关的线索可能会导致重新巩固，这是一个假设的过程，在这个过程中，原始记忆可能会更新。相比之下，长时间暴露于与药物相关的线索可能会引发消失，这一过程会减少条件反射。在这篇综述中，我们讨论了可能用于干扰药物奖励记忆的重新巩固和消失的药物和非药物操作。药物制剂如β-肾上腺素能受体拮抗剂心得安可以干扰再巩固，从而破坏药物奖励记忆。NMDA受体甘氨酸位点激动剂d -环丝氨酸和d -丝氨酸等药物可以促进消退，从而减弱药物奖励记忆的表达。除药物干预外，利用再巩固和消退的无药行为方法，如“检索后消退”和“ucs -检索消退”，也能有效地消除或抑制药物奖励记忆的回忆。综上所述，药物和非药物调节的重新巩固和消失是有希望的方法来调节药物奖励记忆和防止复发。针对药物奖励记忆的干预是治疗成瘾的有希望的策略。在接触药物相关线索后，药物奖励记忆可以进入两个相反的过程：重新巩固和消失。在此，我们综述了药物奖励记忆的再巩固和消退的药理学和行为调节。
Drug addiction is an aberrant memory that shares the same memory processes as other memories. Brief exposure to drug-associated cues could result in reconsolidation, a hypothetical process during which original memory could be updated. In contrast, longer exposure times to drug-associated cues could trigger extinction, a process that decreases the conditioned responding. In this review, we discuss the pharmacological and non-pharmacological manipulations on the reconsolidation and extinction that could be used to interfere with drug reward memoires. Pharmacological agents such as β-adrenergic receptor antagonist propranolol can interfere with reconsolidation to disrupt drug reward memory. Pharmacological agents such as the NMDA receptor glycine site agonists D-cycloserine and D-serine can facilitate extinction, and then attenuate the expression of drug reward memory. Besides pharmacological interventions, drug-free behavioral approaches by utilizing the reconsolidation and extinction, such as “post-retrieval extinction” and “UCS-retrieval extinction”, are also effective to erase or inhibit the recall of drug reward memory. Taken together, pharmacological and non-pharmacological modulation of reconsolidation and extinction are promising approaches to regulate drug reward memory and prevent relapse. Interventions targeting drug reward memory are promising strategies for addiction treatment. After exposure to drug-associated cues, drug reward memory can enter two opposing processes: reconsolidation and extinction. Here, we review the pharmacological and behavioral modulations on the reconsolidation and extinction of drug reward memory.
登录
查看更多内容
影响因子：
3.4
作者：
Exton-McGuinness MT;Lee JL
通讯作者：
Lee JL
DOI：
10.1101/lm.035543.114
发表时间：
2014-09
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Exton-McGuinness MT;Patton RC;Sacco LB;Lee JL
通讯作者：
Lee JL
影响因子：
56.9
作者：
Berman, DE;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
56.9
作者：
Eisenberg, M;Kobilo, T;Dudai, Y
通讯作者：
Dudai, Y
影响因子：
2.7
作者：
Fan, Hsin-Yi;Cherng, Chianfang G.;Yu, Lung
通讯作者：
Yu, Lung