Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins.
Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins.
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DOI：
10.1037/a0015713
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发表时间：
2009-06
影响因子：
3.7
通讯作者：
Pedersen, Nancy L.
中科院分区：
文献类型：
--
作者：
Brommelhoff, Jessica A.;Gatz, Margaret;Johansson, Boo;McArdle, John J.;Fratiglioni, Laura;Pedersen, Nancy L.
这项研究测试了抑郁症史是否与痴呆症的可能性增加有关，并验证了生命早期的第一次抑郁发作是否与痴呆症的可能性增加有关，或者是否只有在痴呆症诊断时间附近发生的抑郁发作与痴呆症有关。抑郁症信息是从国家医院出院登记处、病史和医疗记录中收集的。使用DSM-IV标准对痴呆进行临床诊断。病例对照结果显示，最近登记识别抑郁症的个体患痴呆症的可能性是没有登记识别抑郁症史的人的3.9倍，而早期登记识别抑郁症与痴呆症风险增加无关。抑郁症发作和痴呆症发作或审查年龄之间的差异每增加1年，痴呆症的可能性就会降低8.4%。双胞胎对照分析发现，患有抑郁症的人患痴呆症的可能性是非抑郁症双胞胎伴侣的3.0倍，并且抑郁症发病年龄梯度相似。总的来说，这些发现表明，在部分控制了遗传影响后，许多人的晚年抑郁症可能是痴呆症的前驱症状，而不是风险因素。
This study tested whether history of depression is associated with an increased likelihood of having dementia, and to verify whether a first depressive episode earlier in life is associated with an increased likelihood of dementia, or whether only depressive episodes occurring close in time to dementia diagnosis are related to dementia. Depression information was collected from national hospital discharge registries, medical history, and medical records. Dementia was clinically diagnosed using DSM-IV criteria. Case-control results showed that individuals with recent registry-identified depression were 3.9 times more likely than those with no registry-identified depression history to have dementia, while registry-identified depression earlier in life was not associated with an increased dementia risk. Each 1-year increase in the difference between depression onset and dementia onset or censored age decreased the likelihood of dementia by 8.4%. Co-twin control analyses found that individuals with prior depression were 3.0 times more likely to have dementia than their non-depressed twin partner, with a similar gradient of age of depression onset. Taken together, these findings suggest that after partially controlling for genetic influences, late-life depression for many individuals may be a prodrome rather than a risk factor for dementia.
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影响因子：
6.6
作者：
Kessing, LV;Mortensen, PB;Bolwig, TG
通讯作者：
Bolwig, TG
影响因子：
9.9
作者：
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作者：
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9.9
作者：
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通讯作者：
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