Identification of Potential Long Non-coding RNA Expression Quantitative Trait Methylations in Lung Adenocarcinoma and Lung Squamous Carcinoma.
Identification of Potential Long Non-coding RNA Expression Quantitative Trait Methylations in Lung Adenocarcinoma and Lung Squamous Carcinoma.
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肺腺癌和肺鳞癌中潜在的长非编码 RNA 表达定量特征甲基化的鉴定
DOI：
10.3389/fgene.2020.602035
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发表时间：
2020
影响因子：
3.7
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Wu X;Gao Y;Bu J;Deng L;Zhang P;Chi M;Jiang L;Shi X;Ning S;Wang G
DNA甲基化与长非编码RNA(LncRNA)的表达有关，也称为lncRNA表达量化性状甲基化(lnc-eQTM)。LNC-eQTM可诱导多种致癌途径。然而，lnc-eQTms还没有被全球识别和研究，它们在肺腺癌(LUAD)和肺鳞癌(LUSC)中的作用也很不清楚。在本研究中，我们在LUAD和LUSC中发现了位于长基因间非编码RNAs(LincRNAs)和其他类型的lncRNAs基因上的一些差异甲基化位点。建立了一个综合管道，在LUAD和LUSC构建两个针对癌症的全球LNC-eQTM调控网络。EQTM之间的联系显示了LUAD和LUSC之间的共同和独特的特征。一些lnc-eQTM也与LUAD和LUSC特异性调控网络中的生存有关。功能分析表明，LNC-eQTM与肿瘤相关功能相关，如肺上皮发育和血管生成。药物再利用分析表明，这些LNC-eQTM可能介导了一些麻醉相关药物在LUAD和LUSC中的作用。综上所述，本研究阐明了lnc-eQTM在LUAD和LUSC中的作用，有助于提高我们对肺癌发病机制的认识，方便治疗。
There are associations between DNA methylation and the expression of long non-coding RNA (lncRNA), also known as lncRNA expression quantitative trait methylations (lnc-eQTMs). Lnc-eQTMs may induce a wide range of carcinogenesis pathways. However, lnc-eQTMs have not been globally identified and studied, and their roles in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) are largely unknown. In the present study, we identified some differential methylation sites located in genes of long intergenic non-coding RNAs (lincRNAs) and other types of lncRNAs in LUAD and LUSC. An integrated pipeline was established to construct two global cancer-specific regulatory networks of lnc-eQTMs in LUAD and LUSC. The associations between eQTMs showed common and specific features between LUAD and LUSC. Some lnc-eQTMs were also related with survival in LUAD- and LUSC-specific regulatory networks. Lnc-eQTMs were associated with cancer-related functions, such as lung epithelium development and vasculogenesis by functional analysis. Drug repurposing analysis revealed that these lnc-eQTMs may mediate the effects of some anesthesia-related drugs in LUAD and LUSC. In summary, the present study elucidates the roles of lnc-eQTMs in LUAD and LUSC, which could improve our understanding of lung cancer pathogenesis and facilitate treatment.
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影响因子：
14.9
作者：
Kuleshov MV;Jones MR;Rouillard AD;Fernandez NF;Duan Q;Wang Z;Koplev S;Jenkins SL;Jagodnik KM;Lachmann A;McDermott MG;Monteiro CD;Gundersen GW;Ma'ayan A
通讯作者：
Ma'ayan A
Lnc2Meth：一个手动管理的数据库，记录与人类疾病相关的长非编码 RNA 和 DNA 甲基化之间的调控关系
影响因子：
14.9
作者：
Zhi H;Li X;Wang P;Gao Y;Gao B;Zhou D;Zhang Y;Guo M;Yue M;Shen W;Ning S;Jin L;Li X
通讯作者：
Li X
影响因子：
2.8
作者：
Kaessmeyer, Sabine;Bhoola, Kanti;Plendl, Johanna
通讯作者：
Plendl, Johanna
DOI：
10.1126/science.1192002
发表时间：
2010-08-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Tsai MC;Manor O;Wan Y;Mosammaparast N;Wang JK;Lan F;Shi Y;Segal E;Chang HY
通讯作者：
Chang HY
影响因子：
2
作者：
Chu, Chin-Nan;Wu, King-Chuen;Chung, Jing-Gung
通讯作者：
Chung, Jing-Gung