Glycosphingolipids of human plasma.
Glycosphingolipids of human plasma.
复制标题
人血浆的糖鞘脂。
DOI：
10.1016/0003-9861(85)90179-1
复制
发表时间：
1985
影响因子：
3.9
通讯作者：
Marcus,DM
中科院分区：
文献类型：
--
作者：
Kundu,SK;Diego,I;Osovitz,S;Marcus,DM
A number of glycosphingolipids, including 10 gangliosides, not previously identified in human plasma have been characterized. The plasma contains 2 μg of lipid-bound sialic acid/ml plasma and 54% of the gangliosides are monosialo, 30% disialo, 10% trisialo, and 6% tetrasialo. Individual glycosphingolipids were purified by high-performance liquid chromatography and thin-layer chromatography, and were characterized on the basis of their chromatographic mobility, carbohydrate composition, hydrolysis by glycosidases, methylation analysis, and immunostaining with anti-glycosphingolipid antibodies. The monosialogangliosides were identified as GM3, GM2sialosyl(2–3)- and sialosyl(2–6)lactoneotetraosylceramides, sialosyllacto-N-nor-hexaosylceramide, and sialosyllacto-N-isooctaosylceramide. The major gangliosides in the polysialo fractions contained a ganglio-N-tetraose backbone and were identified as GD3, GD1a, GD1b, and GQ1b. The most abundant neutral glycosphingolipids were glucosyl, lactosyl, globotriaosyl, globotetraosyl and lactoneotetraosylceramides. The other neutral glycosphingolipids, tentatively identified by immunostaining with monoclonal antibodies, contained H1, Lea, Leb, and lacto-N-fucopentose III (X hapten) Structures.
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使用新型多孔二氧化硅 itrobeads® I 进行脂质的高性能制备柱色谱。 鞘糖脂分子种类的分离
DOI：
10.1016/0005-2760(76)90054-0
发表时间：
1976
期刊：
Biochimica et Biophysica Acta
影响因子：
--
作者：
Ando Susumu;Isobe Miyoko;Nagai Yoshitaka
通讯作者：
Nagai Yoshitaka
影响因子：
--
作者：
Donald M. Marcus;Gerald A. Schwarting
通讯作者：
Gerald A. Schwarting
牛肾上腺髓质神经节苷脂的结构。
影响因子：
2.9
作者：
Howard Price;Samar Kundu;Robert W. Ledeen
通讯作者：
Robert W. Ledeen
影响因子：
3.9
作者：
BREIMER, ME
通讯作者：
BREIMER, ME
影响因子：
6.5
作者：
K. Watanabe;Y. Arao
通讯作者：
Y. Arao