Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors.
Mouse Higher Visual Areas Provide Both Distributed and Specialized Contributions to Visually Guided Behaviors.
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DOI：
10.1016/j.cub.2020.09.015
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发表时间：
2020-12-07
期刊：
影响因子：
--
通讯作者：
Glickfeld LL
中科院分区：
文献类型：
--
作者：
Jin M;Glickfeld LL
大脑皮层的平行处理流将感觉场景的许多不同特征分隔开。然而，有些特征是跨流分布的，这就引出了这样的分布式表示是否以及如何有助于感知的问题。我们确定了初级视觉皮层（V1）和三个关键的高级视觉区域（LM，AL和PM）对方向和对比度的感知的必要性，这两个特征在所有四个区域中都是鲁棒编码的。抑制V1，LM或AL降低了方向辨别和对比度检测的灵敏度，这与这些区域在感官知觉中的作用一致。相比之下，抑制PM选择性地增加了对比度检测期间的误报警率，而对方向辨别没有任何影响。这种效应不是视网膜特异性的，这表明PM的抑制改变了感觉整合或决策过程，而不是局部视觉特征的处理。因此，我们发现，在视觉系统中的分布式表示仍然可以支持更高的视觉皮层区域专门的感知角色。Jin和Glickfeld使用光遗传学方法来询问小鼠高阶区域的感知作用。他们发现LM和AL是感知方向和对比度所必需的，而PM具有明显的非视觉作用。因此，尽管这些特征在视觉系统中具有广泛的代表性，但行为角色是专门化的。
Cortical parallel processing streams segregate many diverse features of a sensory scene. However, some features are distributed across streams, begging the question of whether and how such distributed representations contribute to perception. We determined the necessity of primary visual cortex (V1) and three key higher visual areas (LM, AL and PM) for perception of orientation and contrast, two features that are robustly encoded across all four areas. Suppressing V1, LM or AL decreased sensitivity for both orientation discrimination and contrast detection, consistent with a role for these areas in sensory perception. In comparison, suppressing PM selectively increased false alarm rates during contrast detection, without any effect on orientation discrimination. This effect was not retinotopically-specific, suggesting that suppression of PM altered sensory integration or the decision-making process rather than processing of local visual features. Thus, we find that distributed representations in the visual system can nonetheless support specialized perceptual roles for higher visual cortical areas. Jin and Glickfeld use an optogenetic approach to interrogate the perceptual role of mouse higher-order areas. They find that LM and AL are required for perception of orientation and contrast, while PM has a distinct non-visual role. Thus, despite the broad representation of these features in the visual system, behavioral roles are specialized.
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