Bacterial adhesion and growth reduction by novel rubber-derived oligomers.
Bacterial adhesion and growth reduction by novel rubber-derived oligomers.
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DOI：
10.1016/j.bbrc.2013.07.120
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发表时间：
2013-09-06
影响因子：
3.1
通讯作者：
Milsted, Amy
中科院分区：
文献类型：
--
作者：
Badawy, Hope T.;Pasetto, Pamela;Mouget, Jean-Luc;Pilard, Jean-Francois;Cutright, Teresa J.;Milsted, Amy
关键词：
在医疗领域，附着的细菌可引起与导管、切口、烧伤和医疗植入物相关的感染，特别是在免疫功能低下的患者中。附着的细菌对抗生素的耐药性比寄生细胞高1000倍，这一事实加剧了这个问题。抗生素耐药性在这些和其他生物体中的快速传播导致了寻找防止细菌附着的新方法的显著需求。本研究的目的是评估新型聚合物涂层防止三种医学相关细菌附着的有效性。用铜绿假单胞菌、表皮葡萄球菌和金黄色葡萄球菌对天然橡胶（顺式1，4-聚异戊二烯）改性衍生的低聚物进行试验。不同的低聚物为：PP 04，不含季铵（QA）; MV 067，一个QA; PP 06，三个QA基团。在几乎所有的实验中，只要使用寡聚体，细胞附着就受到不同程度的抑制。PP 06是最有效的，因为它使所有细菌的增殖细胞数减少至少50%。还观察到物种敏感性之间的差异。铜绿假单胞菌是最耐药的细菌，S。金黄色葡萄球菌最敏感。需要进一步的实验来了解这些表面的抗菌性能的全部程度和模式。
In the medical field, attached bacteria can cause infections associated with catheters, incisions, burns, and medical implants especially in immunocompromised patients. The problem is exacerbated by the fact that attached bacteria are ~1000 times more resistant to antibiotics than planktonic cells. The rapid spread of antibiotic resistance in these and other organisms has led to a significant need to find new methods for preventing bacterial attachment. The goal of this research was to evaluate the effectiveness of novel polymer coatings to prevent the attachment of three medically relevant bacteria. Tests were conducted with Pseudomonas aeruginosa, Staphylococcus epidermidis, and Staphylococcus aureus for oligomers derived from modifications of natural rubber (cis 1,4-polyisoprene). The different oligomers were: PP04, with no quaternary ammonium (QA); MV067, one QA; PP06, three QA groups. In almost all experiments, cell attachment was inhibited to various extents as long as the oligomers were used. PP06 was the most effective as it decreased the planktonic cell numbers by at least 50% for all bacteria. Differences between species sensitivity were also observed. P. aeruginosa was the most resistant bacteria tested, S. aureus, the most sensitive. Further experiments are required to understand the full extent and mode of the antimicrobial properties of these surfaces.
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影响因子：
3.1
作者：
Fey PD;Olson ME
通讯作者：
Olson ME
影响因子：
5.8
作者：
Myllymaa, Katja;Levon, Jaakko;Konttinen, Yrjo Tapio
通讯作者：
Konttinen, Yrjo Tapio
影响因子：
2
作者：
Schwab, U;Hu, Y;Boor, KJ
通讯作者：
Boor, KJ
影响因子：
4.3
作者：
Rao, Jayasimha;DiGiandomenico, Antonio;Artamonov, Mykhaylo;Leitinger, Norbert;Amin, Ashok R.;Goldberg, Joanna B.
通讯作者：
Goldberg, Joanna B.
影响因子：
5.8
作者：
Davies, Jane C
通讯作者：
Davies, Jane C