MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells.
MicroRNAs and long noncoding RNAs: new regulators in cell fate determination of mesenchymal stem cells.
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MicroRNA和长非编码RNA：间充质干细胞细胞命运决定的新调节因子
DOI：
10.1039/c9ra06563f
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发表时间：
2019-11-13
期刊：
影响因子：
3.9
通讯作者：
Qian, Airong
中科院分区：
文献类型：
--
作者：
Wu, Zixiang;Liang, Shujing;Kuai, Wenyu;Hu, Lifang;Qian, Airong
Mesenchymal stem cells (MSCs) are multipotent cells that are able to differentiate into numerous cell types, including well-known inherent osteoblasts, adipocytes, and chondrocytes, and other cell types, such as hepatocytes, cardiomyocytes and nerve cells. They have become a favorite source of cell-based therapy. Therefore, knowing the mechanism that determines the cell fate of MSCs is important not only for deep understanding of the MSC function but also for the manipulation of MSCs for clinical application. Recently, studies have demonstrated that microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), the two best studied noncoding RNAs, show key roles in cell fate determination of MSCs by functioning as vital regulators of their target gene expression or signaling transduction. Here, we summarize the characteristics of miRNAs and lncRNAs, and review the recent advances proving their profound involvement in determining the cell fate of MSCs to inherent osteoblast, adipocyte, and chondrocyte cells, and to several key cell types including hepatocytes, cardiomyocytes and nerve cells. This will provide researchers with a deep understanding of the role of miRNAs and lncRNAs in MSCs and provide guidance for future research.
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影响因子：
5.6
作者：
Hu L;Yin C;Zhao F;Ali A;Ma J;Qian A
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DOI：
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发表时间：
2017-12-15
期刊：
Development (Cambridge, England)
影响因子：
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作者：
Barter MJ;Gomez R;Hyatt S;Cheung K;Skelton AJ;Xu Y;Clark IM;Young DA
通讯作者：
Young DA
影响因子：
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作者：
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