Relationship between muscle strength and dyslipidemia, serum 25(OH)D, and weight status among diverse schoolchildren: a cross-sectional analysis.
Relationship between muscle strength and dyslipidemia, serum 25(OH)D, and weight status among diverse schoolchildren: a cross-sectional analysis.
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DOI：
10.1186/s12887-018-0998-x
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发表时间：
2018-02-02
期刊：
影响因子：
2.4
通讯作者：
Sacheck JM
中科院分区：
文献类型：
--
作者：
Blakeley CE;Van Rompay MI;Schultz NS;Sacheck JM
肌肉力量与青年心脏代谢危险因素之间的关系，以及维生素D状况对这种关系的潜在影响，还没有得到很好的理解。本研究调查了不同学龄儿童的肌力和血脂异常、血清25-羟基维生素D [25（OH）D]和体重状况之间的关系。从350名4 - 8年级学生（11.2 ± 1.3岁，49.4%女性，56.3%非白人/高加索人）中收集握力（按性别和体重标准化）、人体测量学（身高和体重转换为BMI z评分[BMIz]）、社会人口统计学、血浆HDL-C和甘油三酯的空腹血浓度以及血清25（OH）D。Logistic回归用于测量标准化握力三分位数与血脂、25（OH）D和体重状况之间的相关性，沿着25（OH）D与血脂异常和体重状况之间的相关性。握力较高的儿童超重/肥胖的几率较低（OR：0.03，95% CI：0.01-0.06，握力最高三分位数与最低三分位数，趋势p < 0.0001），临界/低HDL-C（OR：0.28，95%CI：0.16-0.50，趋势p < 0.0001）和临界/高甘油三酯（OR：0.48，95%CI：0.25-0.92，趋势p < 0.05），调整协变量。在进一步调整BMIz后，血脂和握力之间的关联变得不显著。在握力和25（OH）D之间没有观察到相关性，25（OH）D和临界/低HDL-C或体重状态之间也没有观察到相关性;然而，在BMIz调整前，与维生素D缺乏相比，维生素D充足与临界/高甘油三酯的几率较低相关（OR：0.26，95%CI：0.09-0.74，p < 0.05）。在种族/民族多样化的儿童中，肌肉力量与血脂异常较低相关。需要进行纵向研究，以探讨肌肉力量的变化是否会影响儿童的这种关系，而与体重状况无关。本研究于2012年2月17日在www.clinicaltrials.gov（编号NCT 01537809）上注册。
The relationship between muscle strength and cardiometabolic risk factors in youth, and the potential influence of vitamin D status on this relationship, is not well understood. This study examined associations between muscle strength and dyslipidemia, serum 25-hydroxyvitamin D [25(OH)D], and weight status in diverse schoolchildren. Measures of hand-grip strength (standardized for sex and body weight), anthropometrics (height and weight converted to BMI z-score [BMIz]), sociodemographics, and fasting blood concentrations of plasma HDL-C and triglycerides and serum 25(OH)D were collected from 350 4th-8th grade schoolchildren (11.2 ± 1.3 y, 49.4% female, 56.3% non-white/Caucasian). Logistic regression was used to measure associations between standardized tertiles of grip strength and blood lipids, 25(OH)D, and weight status along with associations between 25(OH)D and dyslipidemia and weight status. Children with higher grip strength had lower odds of overweight/obesity (OR: 0.03, 95% CI: 0.01-0.06, in the highest tertile of grip strength vs. lowest, p for trend< 0.0001), borderline/low HDL-C (OR: 0.28, 95% CI: 0.16-0.50, p for trend< 0.0001), and borderline/high triglycerides (OR: 0.48, 95% CI: 0.25-0.92, p for trend< 0.05), adjusting for covariates. Associations between blood lipids and grip strength became non-significant after further adjustment for BMIz. No association was observed between grip strength and 25(OH)D, nor between 25(OH)D and borderline/low HDL-C or weight status; however, vitamin D sufficiency was associated with lower odds of borderline/high triglycerides compared with vitamin D deficiency (OR: 0.26, 95% CI: 0.09-0.74, p for trend< 0.05) before BMIz adjustment. Among racially/ethnically diverse children, muscle strength was associated with lower dyslipidemia. Longitudinal studies are needed to explore whether changes in muscle strength impact this relationship in children, independent of weight status. This study was registered at www.clinicaltrials.gov (No. NCT01537809) on February 17, 2012.
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影响因子：
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作者：
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通讯作者：
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