Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.
Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty.
复制标题
维生素D：对其对肌肉力量的影响，跌倒风险和脆弱的综述。
DOI：
10.1155/2015/953241
复制
发表时间：
2015
影响因子：
--
通讯作者：
Teta D
中科院分区：
文献类型：
--
作者：
Halfon M;Phan O;Teta D
维生素D是骨骼代谢的主要激素。然而，维生素D受体（VDR）的普遍性表明其可能具有广泛的影响，这导致了新的研究探索维生素D对各种组织的影响，特别是在骨骼肌中的影响。体外研究表明，活性形式的维生素D骨化三醇通过基因组效应作用于肌细胞，其中包括细胞核中的VDR激活，从而驱动细胞分化和增殖。一个假定的跨膜受体可能负责非基因组效应导致钙在肌肉细胞内的快速流入。维生素D缺乏症一直与肌肉功能和性能下降以及残疾增加有关。相反，补充维生素D已被证明可以改善不同环境下的肌肉力量和步态，尤其是老年患者。尽管在meta分析的解释中存在一些争议，但由于维生素D对肌肉细胞的直接作用，维生素D的补充降低了跌倒的风险。最后，低维生素D状态始终与脆弱的表型相关。这就是为什么许多权威建议虚弱的病人补充维生素D的原因。
Vitamin D is the main hormone of bone metabolism. However, the ubiquitary nature of vitamin D receptor (VDR) suggests potential for widespread effects, which has led to new research exploring the effects of vitamin D on a variety of tissues, especially in the skeletal muscle. In vitro studies have shown that the active form of vitamin D, calcitriol, acts in myocytes through genomic effects involving VDR activation in the cell nucleus to drive cellular differentiation and proliferation. A putative transmembrane receptor may be responsible for nongenomic effects leading to rapid influx of calcium within muscle cells. Hypovitaminosis D is consistently associated with decrease in muscle function and performance and increase in disability. On the contrary, vitamin D supplementation has been shown to improve muscle strength and gait in different settings, especially in elderly patients. Despite some controversies in the interpretation of meta-analysis, a reduced risk of falls has been attributed to vitamin D supplementation due to direct effects on muscle cells. Finally, a low vitamin D status is consistently associated with the frail phenotype. This is why many authorities recommend vitamin D supplementation in the frail patient.
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影响因子：
4.2
作者：
BOLAND, R;DEBOLAND, AR;HASSELBACH, W
通讯作者：
HASSELBACH, W
影响因子：
6.2
作者：
Bischoff, HA;Stähelin, HB;Conzelmann, M
通讯作者：
Conzelmann, M
影响因子：
5.8
作者：
Goswami, Ravinder;Vatsa, Manju;Bhatia, Himani
通讯作者：
Bhatia, Himani
影响因子：
3.2
作者：
Gupta, Rajat;Sharma, Uma;Goswami, Ravinder
通讯作者：
Goswami, Ravinder
影响因子：
4
作者：
Capiati, D;Benassati, S;Boland, RL
通讯作者：
Boland, RL