Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.
Imaging markers of structural and functional brain changes that precede cognitive symptoms in risk for Alzheimer's disease.
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DOI：
10.1007/s11682-013-9278-4
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发表时间：
2014-06
影响因子：
3.2
通讯作者：
Brown, Jesse
中科院分区：
文献类型：
--
作者：
Burggren, Alison;Brown, Jesse
关键词：
神经影像学迅速推进了对早期阿尔茨海默病中海马体内部和源自海马体的功能障碍的研究。以前驱受试者为重点，我们将讨论海马亚区结构的变化，海马和皮层其他部位功能活动的变化，以及记忆表现期间白质结构连通性的变化和功能相关模式的变化。我们提供了充分的证据表明，无症状的受试者在认知能力下降之前表现出实质性的可识别的大脑变化，但建议在将这些发现应用于个体患者之前还有重要的工作要完成。
Neuroimaging has rapidly advanced investigations into dysfunction both within and emanating from the hippocampus in early Alzheimer’s disease. Focusing on prodromal subjects, we will discuss structural changes to hippocampal subregions, alterations to functional activity both within the hippocampus and elsewhere in the cortex, as well as changes to structural white matter connectivity and changes to functionally correlated patterns during memory performance. We present ample evidence that asymptomatic subjects demonstrate substantial identifiable brain changes before the onset of cognitive decline, but suggest there is significant work yet to be accomplished before applying these findings to individual patients.
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DOI：
10.1523/jneurosci.0305-12.2012
发表时间：
2012-06-13
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Damoiseaux JS;Seeley WW;Zhou J;Shirer WR;Coppola G;Karydas A;Rosen HJ;Miller BL;Kramer JH;Greicius MD;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
2.1
作者：
Apostolova LG;Green AE;Babakchanian S;Hwang KS;Chou YY;Toga AW;Thompson PM
通讯作者：
Thompson PM
影响因子：
5.7
作者：
Dale, AM;Fischl, B;Sereno, MI
通讯作者：
Sereno, MI
影响因子：
16.2
作者：
de Calignon A;Polydoro M;Suárez-Calvet M;William C;Adamowicz DH;Kopeikina KJ;Pitstick R;Sahara N;Ashe KH;Carlson GA;Spires-Jones TL;Hyman BT
通讯作者：
Hyman BT
影响因子：
7.2
作者：
Burggren, AC;Small, GW;Bookheimer, SY
通讯作者：
Bookheimer, SY