Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic.
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DOI：
10.1371/journal.pone.0011811
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发表时间：
2010-07-28
期刊：
影响因子：
3.7
通讯作者：
Pannuti CS
中科院分区：
文献类型：
--
作者：
Romano CM;de Matos AM;Araújo ES;Villas-Boas LS;da Silva WC;Oliveira OM;Carvalho KI;de Souza AC;Rodrigues CL;Levi JE;Kallas EG;Pannuti CS
登革热病毒（DENV）血清型1，2和3已在巴西引起每年的疫情。在这项研究中，我们报告了在圣保罗州海岸重新引入DENV 2。对2010年流行期间18名登革热患者的部分包膜病毒基因进行测序。系统发育分析显示，该毒株属于美洲/亚洲基因型，与2007年和2008年在里约热内卢流行的病毒密切相关。遗传学也没有表现出聚类的临床表现，表明疾病的严重程度不能解释不同的变异或基因型。美洲/亚洲基因型和圣保罗和里约热内卢（SP/RJ）单系群的最近共同祖先的时间估计分别为40年和10年左右。由于这种病毒于2007年首次在巴西被发现，我们认为它在引起首次有记录的疫情之前已经在该国传播。这是对2010年巴西圣保罗州暴发的首次描述，应有助于控制和监测DENV在流行地区的传播。
Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic analysis showed this strain belongs to the American/Asian genotype and was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008. The phylogeny also showed no clustering by clinical presentation, suggesting that the disease severity could not be explained by distinct variants or genotypes. The time of the most recent common ancestor of American/Asian genotype and the São Paulo and Rio de Janeiro (SP/RJ) monophyletic cluster was estimated to be around 40 and 10 years, respectively. Since this virus was first identified in Brazil in 2007, we suggest that it was already circulating in the country before causing the first documented outbreak. This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas.
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影响因子：
5.8
作者：
Posada, D;Crandall, KA
通讯作者：
Crandall, KA
影响因子：
5.4
作者：
Zhang, CL;Mammen, MP;Holmes, EC
通讯作者：
Holmes, EC
影响因子：
4.2
作者：
NOGUEIRA, RMR;MIAGOSTOVICH, MP;SCHATZMAYR, HG
通讯作者：
SCHATZMAYR, HG
DOI：
10.1590/s1020-49892007001000009
发表时间：
2007-11-01
期刊：
Revista Panamericana de Salud Pública
影响因子：
--
作者：
Nogueira, Rita Maria Ribeiro;Araújo, Josélio Maria Galvão de;Schatzmayr, Hermann Gonçalves
通讯作者：
Schatzmayr, Hermann Gonçalves
影响因子：
2.8
作者：
Miagostovich, MP;Nogueira, RMR;Lanciotti, RS
通讯作者：
Lanciotti, RS