Maternal and Neonatal Outcomes in Women with Metabolic Syndrome and Substance Use Disorder.
Maternal and Neonatal Outcomes in Women with Metabolic Syndrome and Substance Use Disorder.
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代谢综合征和药物使用障碍女性的母亲和新生儿结局。
DOI：
10.3390/life13091933
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发表时间：
2023-09-19
期刊：
影响因子：
--
通讯作者：
Murughiyan U
中科院分区：
文献类型：
--
作者：
Sundaram VL;Lamichhane R;Cecchetti A;Arthur S;Murughiyan U
简介：代谢综合征会增加妊娠期糖尿病、先兆子痫和孕妇早产的风险。同样，患有药物使用障碍的妇女的产科和分娩结果也恶化了。尽管这两种情况是阿巴拉契亚地区主要的医疗保健差异，但迄今为止尚未对该队列的健康结果进行研究。这项研究着眼于这一队列的健康结果。方法和结果：在这项回顾性队列研究中，我们分析了2010年1月至2021年11月期间在卡贝尔亨廷顿医院分娩的27,955名母亲。在控制其他因素后，我们采用卡方检验确定相关性，并采用多元logistic回归方法进行比较，发现MetS与SUD联合显著增加妊娠期糖尿病（p值< 0.001）、先兆子痫（p值< 0.001）、早破（p值< 0.001）、早产（p值< 0.001）等妊娠并发症的发生风险和数量。和新生儿疾病（p值< 0.001）相比，没有或只有MetS或SUD的妇女。结论：与单独存在代谢综合征或SUD的妇女相比，同时存在代谢综合征和药物滥用的妇女妊娠和新生儿结局恶化。总之，分析所有变量对于战略性规划和实施将对孕妇和儿童的健康结果产生积极影响的保健干预措施至关重要。
Introduction: Metabolic syndrome amplifies the risk of gestational diabetes, preeclampsia, and preterm labor in pregnant women. Similarly, women with substance use disorder have worsened obstetric and birth outcomes. Despite these two conditions being major healthcare disparities in Appalachia, the health outcomes of this cohort have not been studied thus far. This study looks at the health outcomes of this cohort. Method and Results: In this retrospective cohort study, we analyzed 27,955 mothers who delivered at Cabell Huntington Hospital between January 2010 and November 2021. We implemented Chi-square tests to determine the associations and multiple logistic regression methods for comparison after controlling for other factors, and found that MetS, together with SUD, significantly increases the risk as well as the number of pregnancy complications such as gestational diabetes (p-value < 0.001), preeclampsia (p-value < 0.001), premature rupture (p-value < 0.001), preterm labor (p-value < 0.001), and newborn disorder (p-value < 0.001) compared to the women who had none or had either MetS or SUD alone. Conclusion: Women with both metabolic syndrome and substance abuse had worsened pregnancy and neonatal outcomes compared to women with metabolic syndrome or SUD alone. In conclusion, analysis of all the variables is crucial to strategically planning and implementing health interventions that will positively influence the health outcome of the pregnant woman as well as the child.
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影响因子：
7.2
作者：
Kuklina EV;Meikle SF;Jamieson DJ;Whiteman MK;Barfield WD;Hillis SD;Posner SF
通讯作者：
Posner SF
影响因子：
8.2
作者：
McAninch, Dale;Bianco-Miotto, Tina;Grieger, Jessica A.
通讯作者：
Grieger, Jessica A.
DOI：
10.1111/j.0963-7214.2006.00421.x
发表时间：
2006-06-01
影响因子：
7.2
作者：
Jones, HE
通讯作者：
Jones, HE
DOI：
10.15585/mmwr.mm7015a1
发表时间：
2021-04-16
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Luo F;Li M;Florence C
通讯作者：
Florence C
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE