Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome.
Catecholamine and cortisol levels during sleep in women with irritable bowel syndrome.
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DOI：
10.1111/j.1365-2982.2009.01351.x
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发表时间：
2009-11
影响因子：
3.5
通讯作者：
Heitkemper MM
中科院分区：
文献类型：
--
作者：
Burr RL;Jarrett ME;Cain KC;Jun SE;Heitkemper MM
有证据表明，肠易激综合征（IBS）患者对环境、身体和内脏刺激反应过度。IBS患者也经常报告睡眠质量差。本研究比较了IBS女性患者（n = 30）和健康对照组（n = 31）睡眠期间的血清皮质醇和血浆儿茶酚胺水平，以及IBS样本中基于主要粪便模式的亚组，IBS腹泻（n = 14），IBS便秘（n = 7）和IBS交替者（n = 9）。在睡眠实验室中，从晚上8点到醒来，每20分钟抽取一次连续的血液样本，测量皮质醇，每小时测量一次儿茶酚胺。由于个体参与者的睡眠时间表不同，每个受试者的激素系列时基都参考了他们第2阶段睡眠的开始。总的来说，IBS女性和对照组之间的皮质醇或儿茶酚胺模式没有显着差异，也没有任何组的时间相互作用。然而，便秘型IBS的女性在整个睡眠间隔中表现出显著增加的去甲肾上腺素，肾上腺素和皮质醇水平，而便秘型IBS的女性去甲肾上腺素和皮质醇水平显著降低。这些结果表明，IBS占主导地位的肠道类型亚组之间的睡眠期间神经内分泌水平的差异可能大于IBS女性和对照组之间的差异。睡眠期间的神经内分泌概况可能有助于我们理解IBS的症状表达。
Evidence suggests that patients with irritable bowel syndrome (IBS) are hyper-responsive to environmental, physical, and visceral stimuli. IBS patients also frequently report poor sleep quality. This study compared serum cortisol and plasma catecholamine levels during sleep between women with IBS (n = 30) and healthy controls (n = 31), and among subgroups within the IBS sample based on predominant stool patterns, IBS-diarrhea (n = 14), IBS-constipation (n = 7), and IBS-alternators (n = 9). Cortisol was measured from serial blood samples drawn every 20 minutes, and catecholamines every hour, in a sleep laboratory from 8 PM until awakening. Because of the varied sleep schedules of the individual participants, each subject’s hormone series time base was referenced with respect to their onset of Stage-2 sleep. Overall, there were no significant differences in cortisol or catecholamine patterns between women with IBS and controls, nor were there any group by time interactions. However, women with constipation-predominant IBS demonstrated significantly increased norepinephrine, epinephrine, and cortisol levels throughout the sleep interval, and women with diarrhea-predominant IBS were significantly lower on norepinephrine and cortisol. These results suggest that differences in neuroendocrine levels during sleep among IBS predominant bowel pattern subgroups may be greater than differences between IBS women and controls. Neuroendocrine profiles during sleep may contribute to our understanding of symptom expression in IBS.
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