Association Between Metabolic Syndrome and Radiographic Hand Osteoarthritis: Data From a Community-Based Longitudinal Cohort Study.
Association Between Metabolic Syndrome and Radiographic Hand Osteoarthritis: Data From a Community-Based Longitudinal Cohort Study.
复制标题
DOI：
10.1002/acr.23288
复制
发表时间：
2018-03
影响因子：
4.7
通讯作者：
Haugen IK
中科院分区：
文献类型：
--
作者：
Strand MP;Neogi T;Niu J;Felson DT;Haugen IK
使用 Framingham 研究的纵向数据探讨代谢综合征 (MetS) 及其组成部分是否与手部 OA 相关。在我们的横断面分析中，我们纳入了 1089 人（年龄 50-75 岁），其中 785 人进行了 7 年的纵向 X 线照片。其中，586 名基线时没有手部 OA 的患者被纳入手部 OA 发生率分析中。我们使用逻辑回归分析并调整年龄、性别和体重指数 (BMI)，探讨了 MetS 及其组成部分（向心性肥胖、高血压、糖尿病、甘油三酯血症、低高密度脂蛋白）与放射学手部 OA（定义为≥2 个指间关节且 Kellgren-Lawrence 分级≥2）之间的关联。在纵向分析中，MetS 被用作 Kellgren-Lawrence 总评分和手部 OA 变化的预测因子。 MetS 与手部 OA 的存在（OR=1.11，95% CI 0.78–1.59）、Kellgren-Lawrence 总分的变化（OR=0.83，95% CI 0.59–1.17）或手部 OA 发生率（OR=0.91，95% CI 0.58–1.44）无关。高血压与手部 OA 的存在存在统计学显着相关性（OR=1.25，95% CI 0.90-1.74），并且与 Kellgren-Lawrence 总评分的变化存在统计学显着相关性（OR=1.47，95% CI 1.08-1.99）。没有证明一致的剂量反应关系（数据未显示）。此外，高血压与手部 OA 发生率并无统计学显着相关性（OR=1.23，95% CI 0.82-1.83）。 MetS 和糜烂性手部 OA 之间没有发现统计学上显着的关联。我们发现 MetS 和手部 OA 之间没有关联。高血压在手部 OA 发病机制中的作用值得进一步研究。
To explore whether metabolic syndrome (MetS) and its components are associated with hand OA using longitudinal data from the Framingham study. In our cross-sectional analyses we included 1089 persons (age 50–75 years), of whom 785 had 7-year longitudinal radiographs. Of these, 586 with no hand OA at baseline were included in analyses on hand OA incidence. We explored associations between and MetS and its components (central obesity, hypertension, diabetes, triglyceridemia, low high-density lipoprotein) and radiographic hand OA (defined as ≥2 interphalangeal joints with Kellgren-Lawrence grade≥2) using logistic regression analyses with adjustment for age, sex and body mass index (BMI). In longitudinal analyses, MetS was used as predictor for change in Kellgren-Lawrence sum score and incident hand OA. MetS was not associated with hand OA presence (OR=1.11, 95% CI 0.78–1.59), change in Kellgren-Lawrence sum score (OR=0.83, 95% CI 0.59–1.17) or hand OA incidence (OR=0.91, 95% CI 0.58–1.44). Hypertension was borderline statistically significantly associated with hand OA presence (OR=1.25, 95% CI 0.90–1.74), and a statistically significant association was found for change in Kellgren-Lawrence sum score (OR=1.47, 95% CI 1.08–1.99). Consistent dose-response relationships were not demonstrated (data not shown). Furthermore, hypertension was not statistically significantly associated with hand OA incidence (OR=1.23, 95% CI 0.82–1.83). No statistically significant associations were found between MetS and erosive hand OA. We found no association between MetS and hand OA. The role of hypertension in hand OA pathogenesis warrants further investigation.
登录
查看更多内容
影响因子：
7
作者：
Marshall, M.;Peat, G.;Nicholls, E.;van der Windt, D.;Myers, H.;Dziedzic, K.
通讯作者：
Dziedzic, K.
影响因子：
7
作者：
Wen, C. Y.;Chen, Y.;Chiu, K. Y.
通讯作者：
Chiu, K. Y.
影响因子：
27.4
作者：
Visser, A. W.;de Mutsert, R.;Kloppenburg, M.
通讯作者：
Kloppenburg, M.
影响因子：
27.4
作者：
Dahaghin, S.;Bierma-Zeinstra, S. M. A.;Pols, H. A. P.
通讯作者：
Pols, H. A. P.
影响因子：
2.1
作者：
Calvet, J.;Orellana, C.;Gratacos, J.
通讯作者：
Gratacos, J.