Lesions of the dorsal noradrenergic bundle impair attentional set‐shifting in the rat
Lesions of the dorsal noradrenergic bundle impair attentional set‐shifting in the rat
复制标题
背侧去甲肾上腺素能束损伤损害大鼠注意力转移
DOI：
10.1111/j.1460-9568.2007.05612.x
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发表时间：
2007
影响因子：
3.4
通讯作者：
T. Robbins
中科院分区：
文献类型：
--
作者：
D. Tait;V. Brown;A. Farovik;D. Theobald;J. Dalley;T. Robbins
内侧前额叶皮层（mPFC）损伤的大鼠在注意力集中转移方面受损，当它被要求转移到先前无关的感知维度时。去甲肾上腺素能输入到mPFC的主要来源是蓝斑通过背侧去甲肾上腺素能升束（DNAB）。本研究考察了6 -羟多巴胺诱导的DNAB损伤后选择性皮质去甲肾上腺素耗损对注意力集中转移和其他辨别学习和表现方面的影响。老鼠学会了在有饵的碗里挖洞，然后根据碗的气味或挖洞介质的两个方面中的一个来获得辨别能力。当意外事件被相同的刺激逆转时，该任务测试了新辨别（包括内维和外维）的习得和反转学习。在测试的结论中，DNAB损伤的大鼠在mPFC（扣带和前边缘皮层亚区）中选择性地消耗了约70%的去甲肾上腺素，而多巴胺或5 -羟色胺没有其他显著变化。当需要注意转移时（额外维度转移），大鼠需要更多的试验来学习新的区分。与对照组相比，背侧去肾上腺素能上升束（DNAB）损伤的大鼠在需要ED移位时，在新习得方面受损，但在逆向学习和其他方面的辨别学习方面没有受损。这些数据与其他证据一致，表明去甲肾上腺素（NA）与注意力集中转移有关，并与内侧前额叶皮层（mPFC）内5‐羟色胺（5‐HT）和乙酰胆碱的影响形成对比。这些发现也与最近关于蓝脑-皮质去肾上腺素能系统功能的理论化有关。
Rats with medial prefrontal cortex (mPFC) lesions are impaired in attentional set‐shifting, when it is required to shift to a previously irrelevant perceptual dimension. The main source of noradrenergic input to the mPFC is from the locus coeruleus via the dorsal noradrenergic ascending bundle (DNAB). This study examined the effects of selective cortical noradrenaline depletion following 6‐hydroxydopamine‐induced lesions of the DNAB on attentional set‐shifting and other aspects of discrimination learning and performance. Rats learned to dig in baited bowls, and then acquired discriminations based on one of two aspects of a bowl − odour or digging medium. The task tested acquisition of novel discriminations (both intra‐ and extra‐dimensional) and reversal learning when contingencies were reversed with the same stimuli. At the conclusion of testing, the DNAB‐lesioned rats were shown to have a selective depletion of noradrenaline of ∼ 70% within the mPFC (cingulate and prelimbic cortex subregions), with no other significant changes in dopamine or 5‐hydroxytryptamine. Rats required more trials to learn new discriminations when attentional shifting was required [extra‐dimensional (ED)‐shift]. Rats with dorsal noradrenergic ascending bundle (DNAB) lesions were impaired in novel acquisitions when an ED‐shift was required, but were unimpaired in reversal learning and other aspects of discrimination learning, relative to controls. These data are consistent with other evidence implicating noradrenaline (NA) in attentional set‐shifting, and contrast with effects of manipulations of 5‐hydroxytryptamine (5‐HT) and acetylcholine within the medial prefrontal cortex (mPFC). The findings are also relevant to recent theorizing about the functions of the coeruleo‐cortical noradrenergic system.
前边缘-下边缘区域多巴胺 D(1) 受体阻断对行为灵活性的影响。
DOI：
10.1101/lm.45802
发表时间：
2002
期刊：
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子：
--
作者：
Ragozzino,MichaelE
通讯作者：
Ragozzino,MichaelE
影响因子：
14.5
作者：
Fellows, LK;Farah, MJ
通讯作者：
Farah, MJ
影响因子：
56.9
作者：
Usher, M;Cohen, JD;Aston-Jones, G
通讯作者：
Aston-Jones, G