Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis.
Anti-cyclic citrullinated peptide antibodies in primary Sjögren syndrome may be associated with non-erosive synovitis.
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DOI：
10.1186/ar2420
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发表时间：
2008
影响因子：
4.9
通讯作者：
Caporali R
中科院分区：
文献类型：
--
作者：
Atzeni F;Sarzi-Puttini P;Lama N;Bonacci E;Bobbio-Pallavicini F;Montecucco C;Caporali R
本研究的目的是调查原发性干燥综合征（pSS）患者中环瓜氨酸肽抗体（抗CCP）的患病率及其与临床和实验室数据的相关性。我们分析了155例pSS患者的临床和血清学资料。其中，14例因符合美国风湿病学会类风湿性关节炎（RA）标准而被排除。因此，临床评估了141例患者（27例男性和114例女性;平均年龄48岁，范围39 - 60岁）是否存在滑膜炎（一个或多个关节的客观肿胀）和腺体外受累。使用市售的第二代酶联免疫吸附试验检测抗CCP抗体。用比浊法测定IgM类风湿因子（RF）。14例患者（9.9%）有中度至高度抗CCP，94例（66.7%）RF阳性。81例（57.4%）表现为腺体外受累，44例（31.2%）有滑膜炎，无任何侵蚀的放射学征象。抗CCP抗体的存在与滑膜炎密切相关（P < 0.001），但与腺体外受累无关（P = 0.77）。多变量分析证实了抗CCP抗体与滑膜炎患病率增加之间的相关性（抗CCP抗体阳性与阴性的患病率比值比为7.611，95%置信区间为1.475至74.870; P = 0.010）。只有少数pSS患者抗CCP阳性，这似乎与滑膜炎的患病率密切相关。因此，pSS患者的抗CCP阳性可能是未来进展为RA或滑膜组织炎症过程表达的预测因子。
The purpose of this study was to investigate the prevalence of cyclic citrullinated peptide antibodies (anti-CCP) in patients with primary Sjögren syndrome (pSS) and its correlation with clinical and laboratory data. We analysed the clinical and serological data of 155 consecutive patients with pSS. Among these, 14 were excluded due to fulfillment of American College of Rheumatology criteria for rheumatoid arthritis (RA). So, 141 patients (27 males and 114 females; mean age 48 years, range 39 to 60) were clinically assessed for the presence of synovitis (objective swelling of one or more joints) and extra-glandular involvement. The anti-CCP antibodies were tested using a commercially available second-generation enzyme-linked immunosorbent assay. IgM rheumatoid factor (RF) was determined by nephelometry. Fourteen patients (9.9%) had moderate to high levels of anti-CCP, and 94 (66.7%) were positive for RF. Eighty-one (57.4%) showed extra-glandular involvement, and 44 (31.2%) had synovitis without any radiographic sign of erosion. There was a close correlation between the presence of anti-CCP and synovitis (P < 0.001) but no association between anti-CCP and extra-glandular involvement (P = 0.77). Multivariate analysis confirmed the association between anti-CCP and an increased prevalence of synovitis (prevalence odds ratio for positive versus negative anti-CCP status 7.611, 95% confidence interval 1.475 to 74.870; P = 0.010). Only a minority of patients with pSS are anti-CCP-positive, which seems to be closely associated with the prevalence of synovitis. Anti-CCP positivity in patients with pSS therefore may be a predictor of future progress to RA or an expression of the inflammatory process of synovial tissue.
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影响因子：
27.4
作者：
Gottenberg, JE;Mignot, S;Mariette, X
通讯作者：
Mariette, X
影响因子：
27.4
作者：
Tzioufas, AG;Wassmuth, R;Moutsopoulos, HM
通讯作者：
Moutsopoulos, HM
影响因子：
27.4
作者：
Vencovsky, J;Machácek, S;Ruzicková, S
通讯作者：
Ruzicková, S
DOI：
10.1196/annals.1384.003
发表时间：
2007-01-01
期刊：
ORAL-BASED DIAGNOSTICS
影响因子：
--
作者：
Fox, Philip C.
通讯作者：
Fox, Philip C.
影响因子：
4.9
作者：
Bobbio-Pallavicini, F;Alpini, C;Montecucco, C
通讯作者：
Montecucco, C