Comparison of comparable scald and contact burns in a porcine model: A preliminary report.
Comparison of comparable scald and contact burns in a porcine model: A preliminary report.
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DOI：
10.1111/wrr.12848
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Arbab MH
中科院分区：
文献类型：
--
作者：
Singer AJ;Zhou JW;Osman OB;Harris ZB;Khani ME;Baer E;Zhang N;McClain SA;Arbab MH
烫伤和接触性烧伤的深度和愈合是否相似仍有争议。由于水的热容量更大，我们假设当暴露在类似的温度和暴露时间时，由热水引起的烧伤将比与热金属接触引起的烧伤更深。使用黄铜棒或循环热水在两只麻醉的雌性家猪中产生40个标准化烧伤。在一只猪中，温度保持恒定（95° C），而暴露的持续时间变化（5、10、15秒）。在第二只猪中，暴露时间保持恒定（10秒）。而暴露温度变化（70、80、98° C）。定期进行穿刺活检，以确定烧伤深度后立即受伤，烧伤21天内再上皮化的百分比，并在28天的疤痕深度。使用方差分析进行分析。当温度保持恒定时，暴露持续时间（5、10和15秒）与瘢痕深度相关（分别为2.1、3.8和5.0 mm，P=0.001），但与烧伤深度无关（分别为2.0、2.2和2.3 mm，P=0.10）。当暴露时间保持不变时，温度（70、80、98° C）与瘢痕深度相关（0.6 vs 1.7 vs 3.6，P<0.001），但与烧伤深度无关（分别为1.2 vs 1.5 vs 1.7 mm，P=0.21）。烧伤深度大于接触烧伤，虽然没有显着更大。在控制温度后，烫伤和接触性烧伤之间的瘢痕深度差异具有统计学意义（接触性烧伤的边缘平均值为3.0，烫伤为4.3，P=0.008）。我们的结论是，在控制温度和暴露时间时，循环热水在猪体内产生的烧伤比接触黄铜棒产生的烧伤更深。
Whether the depth and healing of scalds and contact burns are similar is controversial. Due to water’s greater heat capacity, we hypothesized that when exposed to similar temperatures and durations of exposure, burns caused by hot water would be deeper than those cause by contact with hot metal. 40 standardized burns were created in two anesthetized female domestic pigs using a brass bar or circulating heated water. In one pig, the temperature was kept constant (95° C) while the duration of exposure varied (5, 10, 15 sec.) In the second pig, the exposure time was kept constant (10 sec.) while the temperature of exposure varied (70, 80, 98° C). Periodic punch biopsies were taken to determine burn depth immediately after injury, percentage burns reepithelialized within 21 days, and depth of scar at 28 days. Analysis was performed using analysis of variance. When temperature was held constant, duration of exposure (5, 10, and 15 sec.) was associated with scar depth (2.1 vs 3.8 vs 5.0 mm respectively, P=0.001) but not with burn depth (2.0 vs 2.2 vs 2.3 mm respectively, P=0.10). When exposure duration was held constant, temperature (70, 80, 98° C) was associated with scar depth (0.6 vs 1.7 vs 3.6, P<0.001) but not with burn depth (1.2 vs 1.5 vs 1.7 mm respectively, P=0.21). Burn depths were greater for scald than contact burns although not significantly greater. After controlling for temperature, the difference in scar depth between scalds and contact burns was statistically significant (marginal means 3.0 for contact burns, 4.3 for scalds, P=0.008). We conclude that burns created in swine with circulating hot water result in deeper scars than those created by contact with a brass bar when controlling for temperature and duration of exposure.
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