Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat.
Regulation of glucose-dependent insulinotropic polypeptide release by protein in the rat.
复制标题
大鼠中蛋白质对葡萄糖依赖性促胰岛素多肽释放的调节。
DOI：
10.1152/ajpgi.2000.279.3.g561
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Tseng,CC
中科院分区：
文献类型：
--
作者：
Wolfe,MM;Zhao,KB;Glazier,KD;Jarboe,LA;Tseng,CC
葡萄糖依赖型促胰岛素多肽(GIP)的释放主要发生在摄入碳水化合物和脂肪之后。这些研究是为了确定蛋白质对大鼠GIP表达的影响。12 0min时十二指肠粘膜GIP浓度由8.4±1.5升至19.8±3.2 ng GIP/mg蛋白(P<0.0 1)。血浆GIP水平从95±5.2pg/ml上升到120min时的峰值289±56.1pg/ml(P<0.01)。为了确定蛋白质对GIP的影响是否是由于刺激胃酸分泌，大鼠预先给予奥美拉唑10 mg/kg，然后部分降低粘膜和血浆GIP浓度。为了进一步观察鲁米那酸的作用，大鼠十二指肠内注射0.1M盐酸120min，显著增加GIP的表达。这些研究表明，营养蛋白为大鼠GIP的表达提供了强有力的刺激，这种影响发生在翻译后水平，可能部分通过蛋白质的酸刺激特性来调节。酸对GIP的影响与GIP在大鼠体内作为肠胃泌素的作用是一致的。
Glucose-dependent insulinotropic polypeptide (GIP) release has been demonstrated predominantly after ingestion of carbohydrate and fat. These studies were conducted to determine the effects of protein on GIP expression in the rat. Whereas no significant changes in duodenal mucosal GIP mRNA levels were detected in response to peptone, the duodenal GIP concentration increased from 8.4 ± 1.5 to 19.8 ± 3.2 ng GIP/mg protein at 120 min (P< 0.01). Plasma GIP levels also increased from 95 ± 5.2 pg/ml to a peak of 289 ± 56.1 pg/ml at 120 min (P< 0.01). To determine whether the effects of protein on GIP were due to stimulation of acid secretion, rats were pretreated with 10 mg/kg omeprazole, after which mucosal and plasma GIP concentrations were partially attenuated. To further examine the effects of luminal acid, rats were administered intraduodenal 0.1 M HCl for 120 min, which significantly enhanced GIP expression. These studies indicate that nutrient protein provides a potent stimulus for GIP expression in the rat, an effect that occurs at the posttranslational level and may be mediated in part through the acid-stimulatory properties of protein. The effects of acid on GIP are consistent with a role for GIP as an enterogastrone in the rat.
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影响因子：
29.4
作者：
Fred B. Thomas;E. L. Mazzaferri;S. Crockett;Hagop S. Mekhjian;Hans D. Gruemer;Samuel Cataland
通讯作者：
Fred B. Thomas;E. L. Mazzaferri;S. Crockett;Hagop S. Mekhjian;Hans D. Gruemer;Samuel Cataland
胃抑制多肽在灌注的离体大鼠胰腺中的促胰岛素作用。
影响因子：
4.8
作者：
R. Pederson;J. Brown
通讯作者：
J. Brown
通过管腔酸度调节小鼠胃生长抑素分泌：局部反馈机制。
影响因子：
29.4
作者：
Schubert,ML;Edwards,NF;Makhlouf,GM
通讯作者：
Makhlouf,GM
影响因子：
29.4
作者：
Wolfe,MM;McGuigan,JE
通讯作者：
McGuigan,JE
DOI：
10.1056/nejm198812293192605
发表时间：
1988
期刊：
The New England journal of medicine
影响因子：
--
作者：
Wolfe,MM;Soll,AH
通讯作者：
Soll,AH