Immunomodulation and anti-inflammatory effects of garlic compounds.
Immunomodulation and anti-inflammatory effects of garlic compounds.
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DOI：
10.1155/2015/401630
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发表时间：
2015
影响因子：
4.1
通讯作者：
Ortuño-Sahagún D
中科院分区：
文献类型：
--
作者：
Arreola R;Quintero-Fabián S;López-Roa RI;Flores-Gutiérrez EO;Reyes-Grajeda JP;Carrera-Quintanar L;Ortuño-Sahagún D
几个世纪以来，人们一直宣称大蒜对健康的益处。然而，直到最近，大蒜及其衍生物才被提议作为维持免疫系统稳态的有希望的候选者。大蒜复杂的生物化学特性使得加工过程中的变化成为可能，从而产生最终成分和化合物比例不同的不同制剂。在这篇综述中，我们评估了最新的实验结果，表明大蒜似乎可以通过刺激某些细胞类型（例如巨噬细胞、淋巴细胞、自然杀伤（NK）细胞、树突状细胞和嗜酸性粒细胞）来增强免疫系统的功能，其机制包括调节细胞因子分泌、免疫球蛋白产生、吞噬作用和巨噬细胞激活。最后，由于免疫功能障碍在多种疾病的发生和进展中发挥着重要作用，我们仔细研究了大蒜提取物和分离化合物的免疫调节作用，这有助于治疗和预防肥胖、代谢综合征、心血管疾病、胃溃疡甚至癌症等疾病。我们得出的结论是，苜蓿调节细胞因子分泌，并且这种调节可能为其许多治疗效果提供作用机制。
The benefits of garlic to health have been proclaimed for centuries; however, only recently have Allium sativum and its derivatives been proposed as promising candidates for maintaining the homeostasis of the immune system. The complex biochemistry of garlic makes it possible for variations in processing to yield different preparations with differences in final composition and compound proportion. In this review, we assess the most recent experimental results, which indicate that garlic appears to enhance the functioning of the immune system by stimulating certain cell types, such as macrophages, lymphocytes, natural killer (NK) cells, dendritic cells, and eosinophils, by mechanisms including modulation of cytokine secretion, immunoglobulin production, phagocytosis, and macrophage activation. Finally, because immune dysfunction plays an important role in the development and progress of several diseases, we critically examined immunoregulation by garlic extracts and compounds isolated, which can contribute to the treatment and prevention of pathologies such as obesity, metabolic syndrome, cardiovascular disorders, gastric ulcer, and even cancer. We concluded that A. sativum modulates cytokine secretion and that such modulation may provide a mechanism of action for many of their therapeutic effects.
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影响因子：
5.8
作者：
D'Elios, MM;Amedei, A;Del Prete, G
通讯作者：
Del Prete, G
影响因子：
3
作者：
Feng Y;Zhu X;Wang Q;Jiang Y;Shang H;Cui L;Cao Y
通讯作者：
Cao Y
影响因子：
2
作者：
Aboelhadid, S. M.;Kamel, A. A.;Shokier, K. A.
通讯作者：
Shokier, K. A.
影响因子：
2.6
作者：
Fridman, S.;Sinai, T.;Zilberg, D.
通讯作者：
Zilberg, D.
影响因子：
4.7
作者：
AMAGASE, H;MILNER, JA
通讯作者：
MILNER, JA