Quantitative assessment of the timing and tuning of visual-related, saccade-related, and delay period activity in primate central thalamus.
Quantitative assessment of the timing and tuning of visual-related, saccade-related, and delay period activity in primate central thalamus.
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灵长类中央丘脑视觉相关、扫视相关和延迟期活动的时间和调节的定量评估。
DOI：
10.1152/jn.00064.2003
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发表时间：
2003
影响因子：
2.5
通讯作者：
Stanford,TerrenceR
中科院分区：
文献类型：
--
作者：
Wyder,MelanieT;Massoglia,DinoP;Stanford,TerrenceR
本研究探讨了灵长类动物中央丘脑内几个核团的视觉特性。这些核团可能被认为是眼丘脑（OcTh）的组成部分，位于内髓板内和边界处。这些核团与许多皮质和皮质下视觉区有广泛的解剖学联系，包括额叶眼区、辅助眼区、前额叶皮质、后顶叶皮质、尾状核和黑质网状部。以前的单单位记录表明，神经元在自发性扫视和视觉刺激在没有任何特定的行为要求的情况下，在OcTh的反应，但与自愿的，目标导向的运动，这些领域的活动缺乏一个彻底的帐户。我们记录了灵长类动物中央丘脑的单个神经元在视觉引导的延迟眼跳任务中的活动。该样品主要由中央外侧和旁中央板内核和腹前和腹外侧核的腹板区域的神经元组成。在每个区域中观察到对任务的感觉、延迟和运动阶段有反应的神经元，其中许多神经元在多个任务期间被调制。在整个人群中，眼跳相关活动的质量和时间的变化表明参与了从产生眼跳（前眼跳）到记录其后果（例如，传出拷贝）。最后，许多神经元被发现携带空间信息在延迟期间，这表明中央丘脑在视觉控制的高阶方面的作用。
This study investigates the visuomotor properties of several nuclei within primate central thalamus. These nuclei, which might be considered components of an oculomotor thalamus (OcTh), are found within and at the borders of the internal medullary lamina. These nuclei have extensive anatomical links to numerous cortical and subcortical visuomotor areas including the frontal eye fields, supplementary eye fields, prefrontal cortex, posterior parietal cortex, caudate, and substantia nigra pars reticulata. Previous single-unit recordings have shown that neurons in OcTh respond during self-paced spontaneous saccades and to visual stimuli in the absence of any specific behavioral requirement, but a thorough account of the activity of these areas in association with voluntary, goal-directed movement is lacking. We recorded activity from single neurons in primate central thalamus during performance of a visually guided delayed saccade task. The sample consisted primarily of neurons from the centrolateral and paracentral intralaminar nuclei and paralaminar regions of the ventral anterior and ventral lateral nuclei. Neurons responsive to sensory, delay, and motor phases of the task were observed in each region, with many neurons modulated during multiple task periods. Across the population, variation in the quality and timing of saccade-contingent activity suggested participation in functions ranging from generating a saccade (presaccadic) to registering its consequences (e.g., efference copy). Finally, many neurons were found to carry spatial information during the delay period, suggesting a role for central thalamus in higher-order aspects of visuomotor control.
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影响因子：
2.5
作者：
BARASH, S;BRACEWELL, RM;ANDERSEN, RA
通讯作者：
ANDERSEN, RA
影响因子：
2.5
作者：
BOCH, RA;GOLDBERG, ME
通讯作者：
GOLDBERG, ME
影响因子：
2.5
作者：
FUNAHASHI, S;BRUCE, CJ;GOLDMANRAKIC, PS
通讯作者：
GOLDMANRAKIC, PS
未麻醉猴子扫视和眼球运动后额部眼区神经元的放电
影响因子：
2
作者：
E. Bizzi
通讯作者：
E. Bizzi
影响因子：
2.5
作者：
M. Sommer;Robert H. Wurtz
通讯作者：
Robert H. Wurtz