Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California.
Prenatal Exposure to Ambient Pesticides and Preterm Birth and Term Low Birthweight in Agricultural Regions of California.
复制标题
DOI：
10.3390/toxics6030041
复制
发表时间：
2018-07-21
期刊：
影响因子：
4.6
通讯作者：
Ritz B
中科院分区：
文献类型：
--
作者：
Ling C;Liew Z;von Ehrenstein OS;Heck JE;Park AS;Cui X;Cockburn M;Wu J;Ritz B
到目前为止，关于产前接触杀虫剂和不良出生结果的研究结果一直模棱两可。我们研究了产前暴露于农药与早产和足月低出生体重的关系，分别在1998年至2010年出生的儿童中，从加州出生记录中随机选择。我们估计居民暴露于农业应用的农药在出生时的住宅地址2公里内的怀孕三个月的17个单独的农药和三个化学类（有机磷，拟除虫菊酯，氨基甲酸酯）。在任何农业杀虫剂应用2公里范围内的产妇地址中，我们确定了24，693名早产儿和220，297名足月儿，4412名足月低出生体重儿和194，732名足月正常出生体重儿。妊娠早期或中期暴露于个别农药（例如，草甘膦、百草枯、吡虫啉）或接触三种化学品类别中的两种或两种以上农药与早产风险略有增加（3-7%）有关;对雌性后代的影响更大。我们没有发现长期低出生体重与接触腈菌唑以外的农药（OR：1.11; 95% CI：1.04-1.20）和可能的拟除虫菊酯类之间的关联。我们改进的暴露评估显示，妊娠早期和中期暴露于农药与早产有关，但很少与足月低出生体重有关。
Findings from studies of prenatal exposure to pesticides and adverse birth outcomes have been equivocal so far. We examined prenatal exposure to agricultural pesticides in relation to preterm birth and term low birthweight, respectively, in children born between 1998 and 2010, randomly selected from California birth records. We estimated residential exposure to agriculturally applied pesticides within 2 km of residential addresses at birth by pregnancy trimester for 17 individual pesticides and three chemical classes (organophosphates, pyrethroids, and carbamates). Among maternal addresses located within 2 km of any agricultural pesticide application, we identified 24,693 preterm and 220,297 term births, and 4412 term low birthweight and 194,732 term normal birthweight infants. First or second trimester exposure to individual pesticides (e.g., glyphosates, paraquat, imidacloprid) or exposure to 2 or more pesticides in the three chemical classes were associated with a small increase (3–7%) in risk for preterm birth; associations were stronger for female offspring. We did not find associations between term low birthweight and exposure to pesticides other than myclobutanil (OR: 1.11; 95% CI: 1.04–1.20) and possibly the pyrethroids class. Our improved exposure assessment revealed that first and second trimester exposure to pesticides is associated with preterm delivery but is rarely linked with term low birthweight.
登录
查看更多内容
影响因子：
--
作者：
Chen SJ;Liu YL;Sytwu HK
通讯作者：
Sytwu HK
影响因子：
10.4
作者：
Eskenazi B;Harley K;Bradman A;Weltzien E;Jewell NP;Barr DB;Furlong CE;Holland NT
通讯作者：
Holland NT
影响因子：
3.3
作者：
Beuret, CJ;Zirulnik, F;Giménez, MS
通讯作者：
Giménez, MS
影响因子：
1.7
作者：
Chen, Hao;Bai, Song;Claggett, Michael
通讯作者：
Claggett, Michael
影响因子：
5
作者：
Bell, EM;Hertz-Picciotto, I;Beaumont, JJ
通讯作者：
Beaumont, JJ