Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions.
Correlation of individual differences in schizotypal personality traits with amphetamine-induced dopamine release in striatal and extrastriatal brain regions.
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DOI：
10.1176/appi.ajp.2010.10020165
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发表时间：
2011-04
期刊：
影响因子：
--
通讯作者：
Zald DH
中科院分区：
文献类型：
--
作者：
Woodward ND;Cowan RL;Park S;Ansari MS;Baldwin RM;Li R;Doop M;Kessler RM;Zald DH
分裂型人格特征与精神分裂症谱系障碍有关。精神分裂症谱系障碍的个体表现出纹状体多巴胺传递增加。我们试图确定是否在正常变异的个体差异，在纹状体和纹状体外脑区的多巴胺传输相关的典型特征。63名无精神病史的健康个体完成了分裂型人格问卷，并在基线和口服（0.43 mg/kg）d-苯丙胺后接受了[18 F]fallypride的正电子发射断层扫描（PET）成像。多巴胺的释放，量化减去每个受试者的d-安非他明扫描从他们的基线扫描，与分裂型人格问卷总分和因子分数使用区域的利益和体素分析。纹状体中多巴胺的释放与总体的神经元型特征呈正相关。这种关联在纹状体的关联性细分中尤其强大。体素分析确定了多巴胺释放和左额中回和左缘上回的脑型特征之间的其他相关性。对分裂型人格问卷因子评分的探索性分析揭示了纹状体、丘脑、内侧前额叶皮质、颞叶、额叶皮层和下额叶皮质中多巴胺释放与混乱型人格特征之间的相关性。多巴胺信号传导和精神病表型之间的关联延伸到个体差异的正常变异的典型特征，并涉及纹状体和纹状体外脑区的多巴胺传输。D-苯丙胺诱导的多巴胺释放可能是一个有用的内表型研究精神分裂症谱系障碍的遗传基础。
Schizotypal personality traits are associated with schizophrenia spectrum disorders. Individuals with schizophrenia spectrum disorders demonstrate increased dopamine transmission in the striatum. We sought to determine if individual differences in normal variation in schizotypal traits correlate with dopamine transmission in the striatum and extra-striatal brain regions. 63 healthy individuals with no history of psychiatric illness completed the Schizotypal Personality Questionnaire and underwent positron emission tomography (PET) imaging with [18F]fallypride at baseline and after administration of oral (0.43 mg/kg) d-amphetamine. Dopamine release, quantified by subtracting each subject’s d-amphetamine scan from their baseline scan, was correlated with Schizotypal Personality Questionnaire total and factor scores using region-of-interest and voxel-wise analyses. Dopamine release in the striatum positively correlated with overall schizotypal traits. The association was especially robust in the associative sub-division of the striatum. Voxel-wise analyses identified additional correlations between dopamine release and schizotypal traits in the left middle frontal gyrus and left supramarginal gyrus. Exploratory analyses of Schizotypal Personality Questionnaire factor scores revealed correlations between dopamine release and disorganized schizotypal traits in the striatum, thalamus, medial prefrontal cortex, temporal lobe, insula, and inferior frontal cortex. The association between dopamine signaling and psychosis phenotypes extends to individual differences in normal variation in schizotypal traits and involves dopamine transmission in both striatal and extra-striatal brain regions. D-amphetamine induced dopamine release may be a useful endophenotype for investigating the genetic basis of schizophrenia spectrum disorders.
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影响因子：
11.3
作者：
Matheson, Sandra;Langdon, Robyn
通讯作者：
Langdon, Robyn
影响因子：
4.6
作者：
Chen, WJ;Hsiao, CK;Lin, CCH
通讯作者：
Lin, CCH
影响因子：
10.6
作者：
Laruelle, M;Abi-Dargham, A;Innis, R
通讯作者：
Innis, R
影响因子：
5.3
作者：
Kumakura, Yoshitaka;Cumming, Paul;Gruender, Gerhard
通讯作者：
Gruender, Gerhard
DOI：
10.1097/00004647-199601000-00005
发表时间：
1996-01-01
影响因子：
6.3
作者：
Lammertsma, AA;Bench, CJ;Frackowiak, RSJ
通讯作者：
Frackowiak, RSJ