Task-concurrent anodal tDCS modulates bilateral plasticity in the human suprahyoid motor cortex.
Task-concurrent anodal tDCS modulates bilateral plasticity in the human suprahyoid motor cortex.
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任务并发阳极 tDCS 调节人类舌骨上运动皮层的双侧可塑性
DOI：
10.3389/fnhum.2015.00370
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发表时间：
2015
影响因子：
2.9
通讯作者：
He H
中科院分区：
文献类型：
--
作者：
Zhao S;Dou Z;Wei X;Li J;Dai M;Wang Y;Yang Q;He H
经颅直流电刺激（tDCS）是一种调节人类皮质兴奋性的非侵入性方法。在这里，我们检查了当研究参与者执行吞咽任务时，分别以更强和更弱的舌骨上/颏下投影应用于半球时，阳极 tDCS 对舌骨上运动诱发电位 (MEP) 的影响。三十名健康志愿者被邀请参加两次实验，并被随机分配到两个不同组中的一组。在第一组中，刺激针对具有较强舌骨上投影的半球，而第二组则在较弱的舌骨上投影上接受刺激。在随机交叉设计中，tDCS 可用作阳极刺激或假刺激。在干预前立即评估舌骨上 MEP，以及在刺激和未刺激对侧半球刺激停止后 5、30、60 和 90 分钟评估舌骨上 MEP。我们发现阳极 tDCS (a-tDCS) 对两组受刺激侧的舌骨上 MEP 都有长期影响（tDCS 针对较强的预测：F(1,14) = 96.2，p < 0.001；tDCS 针对较弱的预测：F(1,14) = 37.45，p < 0.001）。虽然在刺激较强的预测后从非目标半球引发的 MEP 没有增加（F（1,14）= 0.69，p = 0.42），但我们发现在刺激较弱的预测后（在时间点 30-90 分钟）从非目标半球引发的 MEP 增加（F（1,14）= 18.26，p = 0.001）。我们得出的结论是，阳极 tDCS 对从目标半球和非目标半球引发的舌骨上 MEP 具有不同的影响，具体取决于刺激部位。这一发现对于 a-tDCS 在吞咽困难患者（例如中风后）中的应用可能很重要。
Transcranial direct current stimulation (tDCS) is a non-invasive method to modulate cortical excitability in humans. Here, we examined the effects of anodal tDCS on suprahyoid motor evoked potentials (MEP) when applied over the hemisphere with stronger and weaker suprahyoid/submental projections, respectively, while study participants performed a swallowing task. Thirty healthy volunteers were invited to two experimental sessions and randomly assigned to one of two different groups. While in the first group stimulation was targeted over the hemisphere with stronger suprahyoid projections, the second group received stimulation over the weaker suprahyoid projections. tDCS was applied either as anodal or sham stimulation in a random cross-over design. Suprahyoid MEPs were assessed immediately before intervention, as well as 5, 30, 60, and 90 min after discontinuation of stimulation from both the stimulated and non-stimulated contralateral hemisphere. We found that anodal tDCS (a-tDCS) had long-lasting effects on suprahyoid MEPs on the stimulated side in both groups (tDCS targeting the stronger projections: F(1,14) = 96.2, p < 0.001; tDCS targeting the weaker projections: F(1,14) = 37.45, p < 0.001). While MEPs did not increase when elicited from the non-targeted hemisphere after stimulation of the stronger projections (F(1,14) = 0.69, p = 0.42), we found increased MEPs elicited from the non-targeted hemisphere after stimulating the weaker projections (at time points 30–90 min) (F(1,14) = 18.26, p = 0.001). We conclude that anodal tDCS has differential effects on suprahyoid MEPs elicited from the targeted and non-targeted hemisphere depending on the site of stimulation. This finding may be important for the application of a-tDCS in patients with dysphagia, for example after stroke.
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影响因子：
7.7
作者：
Brunoni, Andre Russowsky;Nitsche, Michael A.;Bolognini, Nadia;Bikson, Marom;Wagner, Tim;Merabet, Lotfi;Edwards, Dylan J.;Valero-Cabre, Antoni;Rotenberg, Alexander;Pascual-Leone, Alvaro;Ferrucci, Roberta;Priori, Alberto;Boggio, Paulo Sergio;Fregni, Felipe
通讯作者：
Fregni, Felipe
影响因子：
8.3
作者：
Kumar S;Wagner CW;Frayne C;Zhu L;Selim M;Feng W;Schlaug G
通讯作者：
Schlaug G
影响因子：
2.9
作者：
Liew SL;Santarnecchi E;Buch ER;Cohen LG
通讯作者：
Cohen LG
影响因子：
2.6
作者：
Daniels, SK;Corey, DM;Foundas, AL
通讯作者：
Foundas, AL
影响因子：
2.5
作者：
Bradnam, Lynley V.;Stinear, Cathy M.;Byblow, Winston D.
通讯作者：
Byblow, Winston D.