High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.
High-density electrode recordings reveal strong and specific connections between retinal ganglion cells and midbrain neurons.
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DOI：
10.1038/s41467-022-32775-2
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发表时间：
2022-09-05
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
上级丘是哺乳动物中脑的一个结构，在视觉引导行为中起着重要作用。上级丘的神经元接受来自视网膜神经节细胞的输入，但这些输入如何在体内整合尚不清楚。在这里，我们发现，高密度电极同时捕捉视网膜轴突和它们的突触后靶神经元在上级丘，在体内的活动。我们发现，在小鼠视网膜神经节细胞轴突提供了一个单一的细胞精确表示视网膜作为输入到上级丘。这种同构映射为精确的视网膜定位布线和功能特异性连接强度构建了支架。我们的方法是广泛适用的，我们证明通过记录视网膜输入的视顶盖在斑胸草雀。我们在小鼠和斑胸草雀中发现了共同的布线规则，这些规则提供了编码在视网膜神经节细胞连接到视网膜受体区域神经元中的视觉世界的精确表示。上级丘接收来自视网膜神经节细胞的视觉信息，但目前还不清楚这些信息在体内是如何组织和整合的。在这里，作者描述了高密度电极如何同时捕获传入轴突和上级丘中目标神经元的活动，并在小鼠和斑马鱼中展示了同构映射和强大而特异的连接。
The superior colliculus is a midbrain structure that plays important roles in visually guided behaviors in mammals. Neurons in the superior colliculus receive inputs from retinal ganglion cells but how these inputs are integrated in vivo is unknown. Here, we discovered that high-density electrodes simultaneously capture the activity of retinal axons and their postsynaptic target neurons in the superior colliculus, in vivo. We show that retinal ganglion cell axons in the mouse provide a single cell precise representation of the retina as input to superior colliculus. This isomorphic mapping builds the scaffold for precise retinotopic wiring and functionally specific connection strength. Our methods are broadly applicable, which we demonstrate by recording retinal inputs in the optic tectum in zebra finches. We find common wiring rules in mice and zebra finches that provide a precise representation of the visual world encoded in retinal ganglion cells connections to neurons in retinorecipient areas. The superior colliculus receives visual information from retinal ganglion cells, but it remains unclear how this information is organized and integrated in vivo. Here the authors describe how high-density electrodes can simultaneously capture the activity of incoming axons and target neurons in the superior colliculus, and demonstrate isomorphic mapping and strong and specific connections in mice and zebrafinches.
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影响因子：
7.7
作者：
Bereshpolova Y;Hei X;Alonso JM;Swadlow HA
通讯作者：
Swadlow HA
影响因子：
7.7
作者：
Barchini J;Shi X;Chen H;Cang J
通讯作者：
Cang J
DOI：
10.1038/newbio231191a0
发表时间：
1971-01-01
期刊：
NATURE-NEW BIOLOGY
影响因子：
--
作者：
CLELAND, BG;DUBIN, MW;LEVICK, WR
通讯作者：
LEVICK, WR
DOI：
10.1007/bf00604008
发表时间：
1988-01-01
影响因子：
2.1
作者：
BISCHOF, HJ
通讯作者：
BISCHOF, HJ
影响因子：
5.3
作者：
Chen, Hui;Savier, Elise L.;Cang, Jianhua
通讯作者：
Cang, Jianhua